Detailed information of TA system TA210190

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 805186..805846
• Replicon: chromosome
• Accession: NZ_CP079837
• Organism: Salmonella enterica subsp. salamae strain LHICA_SA2

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: JMJ84_RS03870
• Protein ID: WP_111770375.1
• Coordinates: 805433..805846 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: S5MU13
• Locus tag: JMJ84_RS03865
• Protein ID: WP_000351186.1
• Coordinates: 805186..805452 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMJ84_RS03845 (801123)	801123..802556	-	1434	WP_023180796.1	6-phospho-beta-glucosidase BglA	-
JMJ84_RS03850 (802714)	802714..803025	+	312	WP_001182973.1	N(4)-acetylcytidine aminohydrolase	-
JMJ84_RS03855 (803189)	803189..803848	+	660	WP_023180797.1	hemolysin III family protein	-
JMJ84_RS03860 (803956)	803956..804936	-	981	WP_219141677.1	tRNA-modifying protein YgfZ	-
JMJ84_RS03865 (805186)	805186..805452	+	267	WP_000351186.1	FAD assembly factor SdhE	Antitoxin
JMJ84_RS03870 (805433)	805433..805846	+	414	WP_111770375.1	protein YgfX	Toxin
JMJ84_RS03875 (805899)	805899..806420	-	522	WP_001055884.1	flavodoxin FldB	-
JMJ84_RS03880 (806533)	806533..807429	+	897	WP_000434302.1	site-specific tyrosine recombinase XerD	-
JMJ84_RS03885 (807453)	807453..808166	+	714	WP_079809264.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
JMJ84_RS03890 (808172)	808172..809905	+	1734	WP_079809265.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16281.27 Da
• Isoelectric Point: 10.7538

>T210190 WP_111770375.1 NZ_CP079837:805433-805846 [Salmonella enterica subsp. salamae]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMLLLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLHPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRIMLQQPISRQH

Nucleotide

• Length: 414 bp

>T210190 NZ_CP104468:55959-56270 [Enterobacter hormaechei]
ATGCACGTAATTTCAAAAGAGCCTTTTGAAGAAGCGGCAAAGCAATATCCCAACGATTCGTTAGCCGTTCGGGCGCTGTA
CCGCTTAGTCCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCGAACGCTGATACCGAGCCTGGACAATTTTAAGTATC
GTAATAAGTGGTGGGTGTTGGATGTAGGGGGCAACAACTTGAGGGTTATCGCCTATATCAATTTCGTGAATAAACGCTTC
TATGTGAAGCACATCGCCACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10550.05 Da
• Isoelectric Point: 6.0783

>AT210190 WP_000351186.1 NZ_CP079837:805186-805452 [Salmonella enterica subsp. salamae]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT210190 NZ_CP104468:56267-56686 [Enterobacter hormaechei]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCATAGCTGCTGTCCCCTTCCTGGGGGGCAGTTCGTC
CGAGAGCGATTACCGCGAAGCGATGGAGTTGGTGGACTATCTGATCGAAAACGACGACGAGAACCCGCTTATTGACTTCC
TTGCGAGTAAAATTGCTGACTATGAGGATAACAGCCCTCGTTTCGCTGAATTCAACAAGGCTATCGCTGAAATGCCGGTC
GGCGTTGCCCTTCTGCGCACCCTGATTGACCAGTACAGGCTGTCTTATTCTGACCTTAAGGAGGAGATCGGCTCTAAATC
GCTGGTTAGCCAGATTCTCTCTGGTCAGCGGTCACTGACAATCATGCACATTAAGGCGCTGTCTGCTCGTTTTGGTGTCA
AACCAGAGTGGTTCCTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A5I0YWH4