Detailed information of TA system TA210186

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4407450..4407966
• Replicon: chromosome
• Accession: NZ_CP079836
• Organism: Salmonella enterica subsp. salamae strain LHICA_SA1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: V1HEI0
• Locus tag: JMJ86_RS21385
• Protein ID: WP_000220584.1
• Coordinates: 4407450..4407734 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JMJ86_RS21390
• Protein ID: WP_079797067.1
• Coordinates: 4407724..4407966 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMJ86_RS21370 (4402670)	4402670..4404322	+	1653	WP_079974597.1	alpha,alpha-phosphotrehalase	-
JMJ86_RS21375 (4404731)	4404731..4406869	+	2139	WP_053507663.1	anaerobic ribonucleoside-triphosphate reductase	-
JMJ86_RS21380 (4406976)	4406976..4407440	+	465	WP_046094240.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
JMJ86_RS21385 (4407450)	4407450..4407734	-	285	WP_000220584.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JMJ86_RS21390 (4407724)	4407724..4407966	-	243	WP_079797067.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JMJ86_RS21395 (4408045)	4408045..4409958	-	1914	WP_141125049.1	BglG family transcription antiterminator	-
JMJ86_RS21400 (4409975)	4409975..4410715	-	741	WP_079974599.1	KDGP aldolase family protein	-
JMJ86_RS21405 (4410712)	4410712..4411830	-	1119	WP_001139196.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
JMJ86_RS21410 (4411814)	4411814..4412947	-	1134	WP_000459961.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-65)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11085.02 Da
• Isoelectric Point: 10.3015

>T210186 WP_000220584.1 NZ_CP079836:c4407734-4407450 [Salmonella enterica subsp. salamae]
MTYELEFDPRALKEWQKLGETVKKQFRKKLVDVLSNPRVESARLRELPDCYKIKLKTSGYRLVYQVQDDVVLVVVIAIGK
REKSAVYRQADKRL

Nucleotide

• Length: 285 bp

>T210186 NZ_CP104453:19612-19899 [Raoultella ornithinolytica]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9041.44 Da
• Isoelectric Point: 5.0651

>AT210186 WP_079797067.1 NZ_CP079836:c4407966-4407724 [Salmonella enterica subsp. salamae]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTVTISDSEDVLLQTVRERLANPQKGIRVSLDDL

Nucleotide

• Length: 243 bp

>AT210186 NZ_CP104453:19373-19612 [Raoultella ornithinolytica]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Structures

Toxin

• AlphaFold DB: A0A741MVA9