Detailed information of TA system TA210185

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4332170..4333808
• Replicon: chromosome
• Accession: NZ_CP079836
• Organism: Salmonella enterica subsp. salamae strain LHICA_SA1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: JMJ86_RS21010
• Protein ID: WP_079797941.1
• Coordinates: 4332170..4333498 (-)
• Length: 443 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A754E9C8
• Locus tag: JMJ86_RS21015
• Protein ID: WP_001314389.1
• Coordinates: 4333503..4333808 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMJ86_RS20985 (4327500)	4327500..4328855	+	1356	WP_079797939.1	replicative DNA helicase	-
JMJ86_RS20990 (4328852)	4328852..4330336	+	1485	WP_079797940.1	chromosome partitioning protein ParB	-
JMJ86_RS20995 (4330320)	4330320..4330859	+	540	WP_000938043.1	DUF2857 domain-containing protein	-
JMJ86_RS21000 (4330878)	4330878..4331774	+	897	WP_219165310.1	STY4528 family pathogenicity island replication protein	-
JMJ86_RS21005 (4331743)	4331743..4332012	+	270	WP_249264787.1	hypothetical protein	-
JMJ86_RS21010 (4332170)	4332170..4333498	-	1329	WP_079797941.1	type II toxin-antitoxin system HipA family toxin	Toxin
JMJ86_RS21015 (4333503)	4333503..4333808	-	306	WP_001314389.1	helix-turn-helix transcriptional regulator	Antitoxin
JMJ86_RS21020 (4334345)	4334345..4334500	+	156	WP_176580895.1	hypothetical protein	-
JMJ86_RS21025 (4334890)	4334890..4337010	+	2121	WP_219165308.1	retron Eco8 family effector endonuclease	-
JMJ86_RS21030 (4337183)	4337183..4338286	+	1104	WP_079974448.1	reverse transcriptase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	4326120..4368117	41997

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (8-108)

Antitoxin

• Cro/C1-type helix-turn-helix domain (20-68)

Sequences

Toxin

Protein

• Length: 443 a.a.
• Molecular weight: 50568.17 Da
• Isoelectric Point: 4.9618

>T210185 WP_079797941.1 NZ_CP079836:c4333498-4332170 [Salmonella enterica subsp. salamae]
MRRTQQRLAIWMNGIRVGFWEKARGEDSLQYLPEWVVDEQGRPLSLSLPFTPGNQLWRGNVVRDYFDNLLPDSEGIRRRL
AVRYQSESLEPFDLLAELGRDCVGAIQLLDVDEEPTDLFSVNYRPLSEADIATTLRNTTAASLPGRQDETDDLRLSIAGA
QEKTALLWHEEQWCLPEGNTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLLLEHYGIPVAKTQIAQFEDQKALVVERF
DRRWSGDRQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMDILSHSDQAEQDKEQFFRAQIIFWLLAATDGHAKNFS
IAIEPQSHYHLTPLYDVLSAWPVIGHGNNQIHWQRCKLAMAVRGSSNYYHIYRIQRRHWINHGELNGLGRRQVESMMDDI
ISSTPEVIERVSALLPESFPLELAECIFDGMRQQCGRLAERG

Nucleotide

• Length: 1329 bp

>T210185 NZ_CP104453:c6116-5811 [Raoultella ornithinolytica]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCTGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11363.02 Da
• Isoelectric Point: 10.1481

>AT210185 WP_001314389.1 NZ_CP079836:c4333808-4333503 [Salmonella enterica subsp. salamae]
MNTVYPLKTLNQIRPLLIGFRKANGLTQKEVSERLGVTQQTYARLEANPASASMERLFRVFTVLGVEMVLSSGPQILSSM
SSSTMDESEQQKDSPARREKW

Nucleotide

• Length: 306 bp

>AT210185 NZ_CP104453:c6336-6118 [Raoultella ornithinolytica]
ATGAAGCAGCGCATCACTGTCACCATAGACAGTGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A754E9C8