Detailed information of TA system TA210184

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3716152..3716772
• Replicon: chromosome
• Accession: NZ_CP079836
• Organism: Salmonella enterica subsp. salamae strain LHICA_SA1

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: JMJ86_RS18210
• Protein ID: WP_001280991.1
• Coordinates: 3716554..3716772 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: JMJ86_RS18205
• Protein ID: WP_000344807.1
• Coordinates: 3716152..3716526 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMJ86_RS18195 (3711289)	3711289..3712482	+	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
JMJ86_RS18200 (3712505)	3712505..3715654	+	3150	WP_001132503.1	efflux RND transporter permease AcrB	-
JMJ86_RS18205 (3716152)	3716152..3716526	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
JMJ86_RS18210 (3716554)	3716554..3716772	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
JMJ86_RS18215 (3716951)	3716951..3717502	+	552	WP_001278785.1	maltose O-acetyltransferase	-
JMJ86_RS18220 (3717618)	3717618..3718088	+	471	WP_000136185.1	YlaC family protein	-
JMJ86_RS18225 (3718143)	3718143..3718283	-	141	WP_001197749.1	type B 50S ribosomal protein L36	-
JMJ86_RS18230 (3718289)	3718289..3718549	-	261	WP_000801414.1	type B 50S ribosomal protein L31	-
JMJ86_RS18235 (3718774)	3718774..3720324	+	1551	WP_000213152.1	EAL domain-containing protein	-
JMJ86_RS18245 (3720555)	3720555..3720944	+	390	WP_077918938.1	MGMT family protein	-
JMJ86_RS18250 (3720977)	3720977..3721546	-	570	WP_000779807.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T210184 WP_001280991.1 NZ_CP079836:3716554-3716772 [Salmonella enterica subsp. salamae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T210184 NZ_CP104452:97195-97680 [Raoultella ornithinolytica]
GTGGGACGTGTAACAGTACCAGAACCTTTATCCAGCTTTCATCAGGTGGCGGAATTCGTTTGCGGTGAAACTGTTCTGGA
TGACTGGTTAAAGCAGAAAGGCCTCAAAAACCAGGCTCTCGGATCGGCCAGAACGTTTGTAGTGTGTAAAAAAGACACGA
AACAAGTAGCCGGTTTTTACTCTCTGGCCACCGGGAGCGTCAACCATACAGAAGCGACAGGCAATCTTCGGCGTAACATG
CCCGATCCCATCCCTGTTATTATACTTGCCCGTCTTGCTGTCGATCTCTCTTTCCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTCACCG
AAGAAGCTAAAAATTTCTACATTCACCATGGTTTCAAACCATCACGAACTCAGCAACGGACATTATTTCTTAAACTCCCT
CAATAG

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT210184 WP_000344807.1 NZ_CP079836:3716152-3716526 [Salmonella enterica subsp. salamae]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT210184 NZ_CP104452:96941-97207 [Raoultella ornithinolytica]
ATGAAATCAGATGTTCAACTTAATCTTAGAGCAAAGGAATCACAGCGGGCGCTCATTGATGCTGCTGCGGAAATTCTTCA
CAAATCACGAACAGACTTCATCCTGGAAATGGCCTGTCAGGCCGCTGAGAACGTGATCCTCGATCGCCGGGTCTTTAATT
TTAACGATGAACAATATGCCGAATTCATCGACATGCTTGATGCCCCTGTTGCAGATGATCCTGCCATAGATAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0