Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 3947308..3948191 Replicon chromosome
Accession NZ_CP079827
Organism Pseudomonas sp. HD6515

Toxin (Protein)


Gene name - Uniprot ID A0A2I0CF56
Locus tag KW568_RS18375 Protein ID WP_004573725.1
Coordinates 3947308..3947745 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID I7C3Q7
Locus tag KW568_RS18380 Protein ID WP_003250525.1
Coordinates 3947742..3948191 (-) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW568_RS18360 (KW568_18190) 3943609..3944838 - 1230 WP_003250533.1 acyl-CoA dehydrogenase -
KW568_RS18365 (KW568_18195) 3944979..3945902 + 924 WP_004573723.1 LysR family transcriptional regulator -
KW568_RS18370 (KW568_18200) 3946096..3947250 + 1155 WP_004573724.1 aminotransferase class V-fold PLP-dependent enzyme -
KW568_RS18375 (KW568_18205) 3947308..3947745 - 438 WP_004573725.1 RES family NAD+ phosphorylase Toxin
KW568_RS18380 (KW568_18210) 3947742..3948191 - 450 WP_003250525.1 DUF2384 domain-containing protein Antitoxin
KW568_RS18385 (KW568_18215) 3948334..3948987 - 654 WP_004573726.1 oxygen-insensitive NAD(P)H-dependent nitroreductase NfsB -
KW568_RS18390 (KW568_18220) 3949091..3950014 + 924 WP_004573727.1 LysR family transcriptional regulator -
KW568_RS18395 (KW568_18225) 3950063..3950893 + 831 WP_003250518.1 AraC family transcriptional regulator -
KW568_RS18400 (KW568_18230) 3950945..3951529 + 585 WP_004573728.1 LysE family transporter -
KW568_RS18405 (KW568_18235) 3951569..3952768 - 1200 WP_003250514.1 sugar transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-138)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(33-91)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15983.24 Da        Isoelectric Point: 6.0704

>T210169 WP_004573725.1 NZ_CP079827:c3947745-3947308 [Pseudomonas sp. HD6515]
VILWRISAYTDLSGTGGLRVSGRWHQAGRPVVYAATSPPGAMLEVLVHLEIDPEDFPTTMRLLRIELPDTVSQAQLPALQ
PGWSAHPELTRTLGNRFLDDGSALLLPVPSAIMPSTTNYLFNPRHPQAQSAKIQVEDFTPDSRLF

Download         Length: 438 bp

>T210169 NZ_CP104447:274831-275133 [Acinetobacter baumannii]
ATGTACTCAATATATACCACTGAAGTCTTTGATGACTGGTTCACCAAGTTAAAAGACCAGCAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAGCCGGTCGGTGAAGGTGTTTCTGAATTACGTTTCT
TCTTTGGGCCAGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTTGTTATTCTTTTAGCAGGCGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTGCAATTGGCACAAGATTTAGAGGAGGAGCTATAA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16956.46 Da        Isoelectric Point: 5.7258

>AT210169 WP_003250525.1 NZ_CP079827:c3948191-3947742 [Pseudomonas sp. HD6515]
MLAEVLRDNGYHEYRARLQALLDIPELASDFEIHTRITDGFAATWLVKLTERGVLTPVERDQIIPLRTLKSRIERDQPLT
VDESDRLFRSAHITAMAEAVFGEAGKAKRWLSKPKERFSGLTPMQMLTTQQGTTQVEEMLLQIAEGYGL

Download         Length: 450 bp

>AT210169 NZ_CP104447:275134-275415 [Acinetobacter baumannii]
ATGGCTATTAAACTTCGCAAATGGGACAGTGCTGAGCATCTTAAAACAGAGGATGATATGCAGGCTTACTTACAAGCATG
TATTGAAGAATCTAATGGCGATGCCGCATTCATTGCAAAGGCTTTAGGTAACATTGCAAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGCTTAGGCCGAGAAAGTCTTTATAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I0CF56

Antitoxin

Source ID Structure
AlphaFold DB I7C3Q7

References