Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relE-higA/HigB-HigA |
| Location | 278653..279644 | Replicon | chromosome |
| Accession | NZ_CP079827 | ||
| Organism | Pseudomonas sp. HD6515 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | KW568_RS01195 | Protein ID | WP_232435437.1 |
| Coordinates | 278653..279129 (+) | Length | 159 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | Q88R60 |
| Locus tag | KW568_RS01200 | Protein ID | WP_004575922.1 |
| Coordinates | 279171..279644 (+) | Length | 158 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KW568_RS01175 (KW568_01175) | 273694..275061 | - | 1368 | WP_004575926.1 | ATP-binding protein | - |
| KW568_RS01180 (KW568_01180) | 275063..275782 | - | 720 | WP_004575925.1 | response regulator | - |
| KW568_RS01185 (KW568_01185) | 275923..278220 | + | 2298 | WP_259537434.1 | TonB-dependent siderophore receptor | - |
| KW568_RS01190 (KW568_01190) | 278388..278594 | - | 207 | WP_003255778.1 | DUF3079 domain-containing protein | - |
| KW568_RS01195 (KW568_01195) | 278653..279129 | + | 477 | WP_232435437.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| KW568_RS01200 (KW568_01200) | 279171..279644 | + | 474 | WP_004575922.1 | transcriptional regulator | Antitoxin |
| KW568_RS01205 (KW568_01205) | 279649..279862 | - | 214 | Protein_230 | integrase | - |
| KW568_RS01210 (KW568_01210) | 280065..280307 | + | 243 | WP_232435436.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KW568_RS01215 (KW568_01215) | 280266..280424 | - | 159 | Protein_232 | helix-turn-helix domain-containing protein | - |
| KW568_RS01220 | 280419..280634 | - | 216 | Protein_233 | integrase | - |
| KW568_RS01225 (KW568_01220) | 280622..280981 | + | 360 | Protein_234 | phage portal protein | - |
| KW568_RS01230 (KW568_01225) | 280995..281348 | - | 354 | WP_146051591.1 | hypothetical protein | - |
| KW568_RS01235 (KW568_01230) | 281597..282139 | - | 543 | WP_004575918.1 | ImmA/IrrE family metallo-endopeptidase | - |
| KW568_RS01240 (KW568_01235) | 282444..283640 | - | 1197 | WP_004575957.1 | IS256 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 282444..283640 | 1196 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 159 a.a. Molecular weight: 18459.43 Da Isoelectric Point: 10.2237
>T210166 WP_232435437.1 NZ_CP079827:278653-279129 [Pseudomonas sp. HD6515]
MTGINPLAIARSPYIAHPDIWLTDIWIRDIFHPMLVRRDNTMRVITKAAVTKAIEAHGQWKAPLSLWLTTFDRATLRFES
FEQLRQTWVTVSGWSVDRIPHSELRPASRKGPLDIYVFDIKKNECRLIAWLNARTGTLYIKAILSHAEYDKWCRSDIR
MTGINPLAIARSPYIAHPDIWLTDIWIRDIFHPMLVRRDNTMRVITKAAVTKAIEAHGQWKAPLSLWLTTFDRATLRFES
FEQLRQTWVTVSGWSVDRIPHSELRPASRKGPLDIYVFDIKKNECRLIAWLNARTGTLYIKAILSHAEYDKWCRSDIR
Download Length: 477 bp
>T210166 NZ_CP104442:4611563-4611883 [Escherichia coli]
ATGAATACTCCAACTGTACCGGCAACGGTGACGGTTTCGTCACGCCTGTCTCCTGTCCAAGTTTGGCAAAAACTATTAAC
GTATATTTTAGAGCATCATTACGGCCTCACGATCAACGACACACCGTTCAGTAACGATACGACGATTCAGGAACATATAG
AGGCTGGAGTGAATCTTACTGATGCTGTTAATTTTCTTGTGGAACGATTCGAGCTGGTGCGCATTGACCAGAAGGGTTTC
TCCTGGCAGGATCAAGAACCCTGGATAACATCTTTGGATGTTCGTCGTGCACAGTTCAACCTTGGCTTGAAACGCTCATA
A
ATGAATACTCCAACTGTACCGGCAACGGTGACGGTTTCGTCACGCCTGTCTCCTGTCCAAGTTTGGCAAAAACTATTAAC
GTATATTTTAGAGCATCATTACGGCCTCACGATCAACGACACACCGTTCAGTAACGATACGACGATTCAGGAACATATAG
AGGCTGGAGTGAATCTTACTGATGCTGTTAATTTTCTTGTGGAACGATTCGAGCTGGTGCGCATTGACCAGAAGGGTTTC
TCCTGGCAGGATCAAGAACCCTGGATAACATCTTTGGATGTTCGTCGTGCACAGTTCAACCTTGGCTTGAAACGCTCATA
A
Antitoxin
Download Length: 158 a.a. Molecular weight: 17229.67 Da Isoelectric Point: 4.4982
>AT210166 WP_004575922.1 NZ_CP079827:279171-279644 [Pseudomonas sp. HD6515]
MKRDKIEANGLDAFIANISPMLDGLNTQMATMAQLLAACHDPIKDDAELEARMALIDELYSHADSEGHAAARFAEMVADR
VYEYESESVLVPFASQAEALAFLLSDRGVKQKDLSAIATQSAVSEILNNKRKMTVAQIKGFAEFFSVPVEFFMHGVV
MKRDKIEANGLDAFIANISPMLDGLNTQMATMAQLLAACHDPIKDDAELEARMALIDELYSHADSEGHAAARFAEMVADR
VYEYESESVLVPFASQAEALAFLLSDRGVKQKDLSAIATQSAVSEILNNKRKMTVAQIKGFAEFFSVPVEFFMHGVV
Download Length: 474 bp
>AT210166 NZ_CP104442:4611164-4611529 [Escherichia coli]
ATGCAGTCGACCACCTTATCCGGCACATCGGCGGAGAACGTATCCTGCCTTCAGTGGGGTTTAAAACGTAATATCACGCC
ATGCTTCGGCGCTCGCCTGGTACAGGAAGGCAACCGCCTATACTTTCTGGCTGACCGGGCAGGATTTAATGGCTCATTCA
GTGACGATGAAGCTTTGCGTCTGGACCAGGCATTTCCACTGATGATGAAACAGCTTGAGCGGATGCTGACGGCTGGCGAG
CTTGATCCTCGCAGCCAGCACTGCGTCACACGGCATCACAACGGACTTACTTGTGAAGCTGACACTCTCGGCTCTCATGG
CTACGTTTACATTGCCATATATCCCCAGTCAGCTCTAACCAGATAA
ATGCAGTCGACCACCTTATCCGGCACATCGGCGGAGAACGTATCCTGCCTTCAGTGGGGTTTAAAACGTAATATCACGCC
ATGCTTCGGCGCTCGCCTGGTACAGGAAGGCAACCGCCTATACTTTCTGGCTGACCGGGCAGGATTTAATGGCTCATTCA
GTGACGATGAAGCTTTGCGTCTGGACCAGGCATTTCCACTGATGATGAAACAGCTTGAGCGGATGCTGACGGCTGGCGAG
CTTGATCCTCGCAGCCAGCACTGCGTCACACGGCATCACAACGGACTTACTTGTGAAGCTGACACTCTCGGCTCTCATGG
CTACGTTTACATTGCCATATATCCCCAGTCAGCTCTAACCAGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|