Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 7459..8027 Replicon plasmid pHD6454-3
Accession NZ_CP079825
Organism Aeromonas veronii strain HD6454

Toxin (Protein)


Gene name parE Uniprot ID A0A0D0R3P1
Locus tag KW556_RS23735 Protein ID WP_011222050.1
Coordinates 7459..7752 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3S7DUI6
Locus tag KW556_RS23740 Protein ID WP_043849769.1
Coordinates 7740..8027 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW556_RS23715 (KW556_23625) 2633..5599 - 2967 WP_053821785.1 Tn3 family transposase -
KW556_RS23720 (KW556_23630) 5602..6162 - 561 WP_053821786.1 recombinase family protein -
KW556_RS23725 (KW556_23635) 6567..6899 - 333 WP_052497043.1 type II toxin-antitoxin system CcdA family antitoxin -
KW556_RS23730 (KW556_23640) 6914..7444 - 531 WP_043849768.1 hypothetical protein -
KW556_RS23735 (KW556_23645) 7459..7752 - 294 WP_011222050.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KW556_RS23740 (KW556_23650) 7740..8027 - 288 WP_043849769.1 CopG family ribbon-helix-helix protein Antitoxin
KW556_RS23745 (KW556_23655) 8200..8400 - 201 WP_103828304.1 hypothetical protein -
KW556_RS23750 (KW556_23660) 8408..8695 - 288 WP_043849770.1 hypothetical protein -
KW556_RS23755 8795..9103 - 309 WP_043849771.1 hypothetical protein -
KW556_RS23760 9104..9640 - 537 WP_043849772.1 hypothetical protein -
KW556_RS23765 9912..10202 + 291 WP_052497044.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10228 10228


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10890.71 Da        Isoelectric Point: 10.8518

>T210164 WP_011222050.1 NZ_CP079825:c7752-7459 [Aeromonas veronii]
MPQVILSPAALRDLKRLREFLHSKSPVVAQRAAQTIRSALAQLGQQPAMGRPIEGLPEVFREWVIPFGDSGYLARYRLEG
ETVVILALRHQREAGFI

Download         Length: 294 bp

>T210164 NZ_CP104442:c4350554-4350027 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.16 Da        Isoelectric Point: 5.1897

>AT210164 WP_043849769.1 NZ_CP079825:c8027-7740 [Aeromonas veronii]
MSAATKPMSIKLDSDTQSRIKQLAAARDRSAHWMMREAITQYVEREERKEAFRRDTLDAWQEFQETGLHVSLEEADQWLA
GWGTEIEGGAPACHK

Download         Length: 288 bp

>AT210164 NZ_CP104442:c4350827-4350561 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D0R3P1

Antitoxin

Source ID Structure
AlphaFold DB A0A3S7DUI6

References