Detailed information of TA system TA210161

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PsyrTA/-
• Location: 3847882..3850460
• Replicon: chromosome
• Accession: NZ_CP079823
• Organism: Aeromonas veronii strain HD6454

Toxin (Protein)

• Gene name: PsyrT
• Uniprot ID: -
• Locus tag: KW556_RS17930
• Protein ID: WP_259583947.1
• Coordinates: 3849261..3850460 (-)
• Length: 400 a.a.

Antitoxin (Protein)

• Gene name: PsyrA
• Uniprot ID: -
• Locus tag: KW556_RS17925
• Protein ID: WP_259583946.1
• Coordinates: 3847882..3849264 (-)
• Length: 461 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KW556_RS17905 (KW556_17840)	3843424..3844254	+	831	WP_232048272.1	hypothetical protein	-
KW556_RS17910 (KW556_17845)	3844708..3846269	+	1562	WP_088813959.1	IS3-like element ISAs20 family transposase	-
KW556_RS17915 (KW556_17850)	3846417..3846965	+	549	WP_011899358.1	hypothetical protein	-
KW556_RS17920 (KW556_17855)	3846983..3847708	-	726	WP_011899359.1	hypothetical protein	-
KW556_RS17925 (KW556_17860)	3847882..3849264	-	1383	WP_259583946.1	DNA-processing protein DprA	Antitoxin
KW556_RS17930	3849261..3850460	-	1200	WP_259583947.1	helicase-related protein	Toxin
KW556_RS17935	3850528..3851379	-	852	WP_259583948.1	DEAD/DEAH box helicase	-
KW556_RS17940 (KW556_17870)	3851394..3851618	-	225	WP_259583949.1	hypothetical protein	-
KW556_RS17945 (KW556_17875)	3851798..3853216	+	1419	WP_004576012.1	IS66-like element ISAs21 family transposase	-
KW556_RS17950 (KW556_17880)	3853199..3854083	-	885	WP_259583950.1	restriction endonuclease subunit S	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	sul1 / aadA16 / catB3 / blaOXA-21 / aac(6')-IIa / aph(3'')-Ib / aph(6)-Id / aac(6')-Ib-cr / qnrVC6 / mph(A) / dfrA27	vgrG2 / vgrG / hcp	3782911..3919363	136452

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Phosphoribosyltransferase domain (269-382)

Antitoxin

• DNA recombination-mediator protein A (93-293)

Sequences

Toxin

Protein

• Length: 400 a.a.
• Molecular weight: 43893.85 Da
• Isoelectric Point: 6.5989

>T210161 WP_259583947.1 NZ_CP079823:c3850460-3849261 [Aeromonas veronii]
VATTALGMGYDKPDLSFVIHYQAPGSIVAYYQQVGRAGRGIDHAVGVLMSGVEDQDIHEFFRESAFPSEAHVHEILQVLE
EADGLSLRGIEEQTNLRHGQIEKVLKLLSVDNPAPVIKDGNQWRRTAVPYQMDHARIAHLTGQRVQEWQEVQAYLTDTSC
KMTFLRRALDDLDPAPCGKCSSCLGHPVINVPVDPGLAHRAGTFLKHAEMVIEPKAQVAAKAFVQYGFRGNLPQNLRAQE
GRVLSRWGDAGWGRTVADNKHAGHFSDELVEAMVAMIQERWLPDPAPQWVCCVPSRNHPALVPDFARRLAARLGLPFIDA
VHKVRDNQPQKGQQNRFHQCQNLDGAFAINQPLPNTPVLLVDDIVDSGWTLTVIAALLQQAGSGAVYPVALASSSVKDS

Nucleotide

• Length: 1200 bp

>T210161 NZ_CP104442:c3607286-3606951 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 461 a.a.
• Molecular weight: 50574.37 Da
• Isoelectric Point: 5.0620

>AT210161 WP_259583946.1 NZ_CP079823:c3849264-3847882 [Aeromonas veronii]
MNVSSPLSATAQATLLLTSYFSKTSSEDAKPLTNAEWGRFALWLKEKSNTPADLLVTDPKALLHGWYDARISVDRIVQLL
NRGHSLAIAMEKWQRAGLWVVTRSDPEYPWRLKQRLKTDSPPVLFGCGNRALLNAGGLAVIGSRNANDEDLMFTNEVGAK
AALERIAIVSGGARGVDETAMLGAMKQDGVVIGVMADSLLKAATSSKWRKGLMDGHAVLVSPFYPEAGFSAGNAMARNKY
IYCLADTSLVIHSGKKGGTLNGAEENLKKFWVPLWVKHTTDKDAANADLVAKGGRWLEADAQTLTIADLMRIEGGRANQV
KEEQVDLFSSMPTQPELFAESKFTLETETETETETETETETEAETEPNPKVAIIEETVVKTTPSETIVEINDHLSSSVDF
YQLFITELQRLASNPIAIDDLIGLTGLHRLQLNDWLKQAENDGVVKKLNRPVRYQVQEKS

Nucleotide

• Length: 1383 bp

>AT210161 NZ_CP104442:c3607534-3607286 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA