Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3838962..3840530 Replicon chromosome
Accession NZ_CP079823
Organism Aeromonas veronii strain HD6454

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag KW556_RS17880 Protein ID WP_244776801.1
Coordinates 3838962..3840275 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag KW556_RS17885 Protein ID WP_103859234.1
Coordinates 3840279..3840530 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW556_RS17850 (KW556_17785) 3834690..3835445 + 756 WP_024945936.1 IS21-like element helper ATPase IstB -
KW556_RS17855 (KW556_17790) 3835525..3836202 - 678 Protein_3465 type VI secretion system tip protein VgrG -
KW556_RS17860 (KW556_17795) 3836214..3836501 - 288 WP_103859239.1 type VI secretion system PAAR protein -
KW556_RS17865 (KW556_17800) 3836678..3837196 - 519 WP_103859238.1 type VI secretion system effector Hcp1 -
KW556_RS17870 (KW556_17805) 3837474..3837992 - 519 WP_244776800.1 hypothetical protein -
KW556_RS17875 (KW556_17810) 3838471..3838965 - 495 WP_103859235.1 hypothetical protein -
KW556_RS17880 (KW556_17815) 3838962..3840275 - 1314 WP_244776801.1 type II toxin-antitoxin system HipA family toxin Toxin
KW556_RS17885 (KW556_17820) 3840279..3840530 - 252 WP_103859234.1 helix-turn-helix domain-containing protein Antitoxin
KW556_RS17890 (KW556_17825) 3840886..3841890 - 1005 WP_181023135.1 tyrosine-type recombinase/integrase -
KW556_RS17895 (KW556_17830) 3841893..3842423 - 531 WP_103859232.1 hypothetical protein -
KW556_RS17900 (KW556_17835) 3842771..3843412 + 642 WP_199416927.1 hypothetical protein -
KW556_RS17905 (KW556_17840) 3843424..3844254 + 831 WP_232048272.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island sul1 / aadA16 / catB3 / blaOXA-21 / aac(6')-IIa / aph(3'')-Ib / aph(6)-Id / aac(6')-Ib-cr / qnrVC6 / mph(A) / dfrA27 vgrG2 / vgrG / hcp 3782911..3919363 136452


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-397)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 48193.41 Da        Isoelectric Point: 6.0549

>T210160 WP_244776801.1 NZ_CP079823:c3840275-3838962 [Aeromonas veronii]
MRMQTLNVAMNGEIVGTLYRDNRGAMSFQYAPEWISEPGSRAISMSLPLSHSRITGSEVFNFFSNLLPDSEAIIARMQAR
FSVETTHPFDLLASVGRDCVGAIQLYSPDADIPTVMETLAEPLDDAQIEQLLEGYQEAPLGMAEDADFRISIAGAQEKTA
LLWYQDCWQRPLGSTPTSHIFKLPIGKIVQNNIDLSESCENEWLCLRIAKAFGFDVANADLATFGKQKVLVVQRFDRRWS
KSGEWLLRLPQEDFCQALGIAPALKYESHGGPGIADAMKLLLGSRLAAKDREQFFKSQILFWMLAAIDGHGKNFSIFIEP
ASSFRMTPLYDVMSAFPIFKSGGIAAQKAKMGMALQGKNRQYHFAMIQPRHFISTAAHVGFPQDTAAQLMLEMATKTEVV
VATVAAELPAGFPEHISNTIFDGLASQAAKILKGVAK

Download         Length: 1314 bp

>T210160 NZ_CP079823:c3840275-3838962 [Aeromonas veronii]
ATGAGAATGCAGACGCTAAACGTGGCGATGAATGGTGAGATCGTAGGCACACTGTACCGAGATAACAGAGGGGCCATGTC
ATTTCAGTATGCCCCAGAGTGGATCTCGGAGCCAGGTTCACGCGCTATTTCCATGTCACTGCCTTTGAGTCATAGCAGGA
TCACAGGAAGTGAAGTCTTCAATTTCTTTAGCAACCTCCTACCTGACTCAGAGGCAATTATTGCCAGGATGCAGGCCCGG
TTCAGCGTTGAGACAACACATCCATTTGATTTGCTGGCGAGTGTTGGCCGGGACTGTGTTGGAGCTATCCAGCTCTATTC
CCCCGATGCTGACATCCCAACTGTAATGGAGACGCTTGCAGAGCCTCTGGATGACGCGCAGATTGAGCAACTGCTTGAAG
GCTATCAGGAAGCTCCCCTTGGGATGGCGGAGGATGCTGATTTCCGGATCTCGATTGCCGGAGCCCAAGAGAAAACTGCA
CTGCTTTGGTACCAAGATTGCTGGCAACGCCCTCTGGGCAGTACGCCAACAAGCCATATTTTTAAGCTACCCATTGGCAA
AATTGTTCAAAATAACATCGACCTCAGCGAGAGTTGCGAGAATGAATGGCTCTGTTTGCGCATTGCAAAGGCCTTCGGAT
TTGACGTCGCCAATGCGGATCTAGCCACGTTCGGCAAGCAGAAGGTGCTTGTCGTTCAGCGTTTTGACCGGCGCTGGTCG
AAATCCGGCGAATGGCTTCTGCGATTGCCCCAAGAAGACTTCTGCCAAGCTCTTGGAATCGCCCCTGCGCTCAAATACGA
GTCCCATGGTGGGCCAGGTATTGCTGATGCAATGAAGTTATTGTTGGGATCCAGACTTGCGGCCAAGGATAGAGAGCAAT
TTTTCAAGTCGCAGATCCTATTCTGGATGTTGGCCGCGATCGATGGGCACGGGAAGAACTTCTCCATCTTCATTGAGCCT
GCATCGTCATTTAGGATGACTCCCCTCTACGATGTCATGTCTGCTTTTCCTATCTTCAAAAGCGGGGGAATTGCAGCTCA
AAAGGCAAAGATGGGGATGGCGCTCCAAGGCAAAAACCGCCAATACCATTTTGCGATGATCCAGCCTCGTCATTTTATCA
GTACCGCCGCCCATGTCGGGTTCCCACAAGATACCGCAGCTCAACTTATGCTCGAAATGGCTACCAAGACAGAGGTGGTG
GTCGCCACAGTAGCCGCCGAGCTGCCAGCCGGTTTCCCAGAACACATTAGCAATACCATCTTCGATGGGCTAGCCAGCCA
GGCGGCTAAGATCTTGAAGGGGGTAGCCAAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9364.82 Da        Isoelectric Point: 9.8930

>AT210160 WP_103859234.1 NZ_CP079823:c3840530-3840279 [Aeromonas veronii]
MKVTSPALLAAAVRDQRKISKLTQAEAAKQVGIKQTTVSDFELRPESTKLETLFKLLSALDLELHVVKRGSTLDDNKVWD
REW

Download         Length: 252 bp

>AT210160 NZ_CP079823:c3840530-3840279 [Aeromonas veronii]
ATGAAAGTAACATCTCCAGCCTTACTTGCGGCTGCGGTTCGTGACCAACGCAAGATCAGCAAGCTAACGCAGGCAGAGGC
GGCGAAACAGGTCGGAATCAAGCAGACAACCGTCTCTGATTTTGAACTACGGCCAGAATCTACCAAGCTGGAGACGCTAT
TCAAGCTCCTTTCTGCTCTGGATCTGGAGCTTCATGTCGTGAAGCGGGGCTCAACATTGGACGATAATAAAGTCTGGGAT
AGGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References