Detailed information of TA system TA210158

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc(toxin)
• Location: 1888028..1888605
• Replicon: chromosome
• Accession: NZ_CP079823
• Organism: Aeromonas veronii strain HD6454

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: KW556_RS08955
• Protein ID: WP_259587000.1
• Coordinates: 1888028..1888426 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: KW556_RS08960
• Protein ID: WP_182969248.1
• Coordinates: 1888426..1888605 (-)
• Length: 60 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KW556_RS08955 (KW556_08935)	1888028..1888426	-	399	WP_259587000.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
KW556_RS08960 (KW556_08940)	1888426..1888605	-	180	WP_182969248.1	hypothetical protein	Antitoxin
KW556_RS08965 (KW556_08950)	1889436..1890884	+	1449	WP_259587006.1	tRNA uracil 4-sulfurtransferase ThiI	-
KW556_RS08970 (KW556_08955)	1890960..1891352	-	393	WP_005333978.1	hypothetical protein	-
KW556_RS08975 (KW556_08960)	1891453..1892085	-	633	WP_005333975.1	trimeric intracellular cation channel family protein	-
KW556_RS08980 (KW556_08965)	1892459..1893328	+	870	WP_042083804.1	flagellin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (45-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14492.52 Da
• Isoelectric Point: 4.1179

>T210158 WP_259587000.1 NZ_CP079823:c1888426-1888028 [Aeromonas veronii]
MDIIQFPPARVLEINHYIIGASPGHQGPASIALLEGALGRIDNAIAYNGLNDVFLIAAKYAMAIGTAHAFSDANKRTGLA
VCLEYLSLNDFEIERDNEKLADAMVDLVLGELPEEWFADILYALWLEEQKTS

Nucleotide

• Length: 399 bp

>T210158 NZ_CP104442:c2764657-2764403 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 60 a.a.
• Molecular weight: 6774.79 Da
• Isoelectric Point: 10.1555

>AT210158 WP_182969248.1 NZ_CP079823:c1888605-1888426 [Aeromonas veronii]
MKDNSVSNKYGLPQVQNRPQIKAEKNLCLNGEEGRQIIKSETKLTLKTHEKTFTRLADM

Nucleotide

• Length: 180 bp

>AT210158 NZ_CP104442:c2764905-2764654 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA