Detailed information of TA system TA210157

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1571617..1572179
• Replicon: chromosome
• Accession: NZ_CP079819
• Organism: Rothia aeria strain LPB0401

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: U7V465
• Locus tag: LPB401_RS06720
• Protein ID: WP_023134146.1
• Coordinates: 1571617..1571985 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: I0UV86
• Locus tag: LPB401_RS06725
• Protein ID: WP_006887478.1
• Coordinates: 1571982..1572179 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPB401_RS06685 (LPB401_06680)	1566870..1568330	-	1461	WP_023134139.1	hypothetical protein	-
LPB401_RS06690 (LPB401_06685)	1568459..1568659	+	201	WP_023134140.1	hypothetical protein	-
LPB401_RS06695 (LPB401_06690)	1568724..1569017	+	294	WP_023134141.1	DUF1778 domain-containing protein	-
LPB401_RS06700 (LPB401_06695)	1569017..1569514	+	498	WP_023134142.1	GNAT family N-acetyltransferase	-
LPB401_RS06705 (LPB401_06700)	1569716..1570261	+	546	WP_023134143.1	PadR family transcriptional regulator	-
LPB401_RS06710 (LPB401_06705)	1570264..1571040	+	777	WP_037286265.1	alpha/beta hydrolase	-
LPB401_RS06715 (LPB401_06710)	1571236..1571481	+	246	WP_023134145.1	GlsB/YeaQ/YmgE family stress response membrane protein	-
LPB401_RS06720 (LPB401_06715)	1571617..1571985	-	369	WP_023134146.1	type II toxin-antitoxin system VapC family toxin	Toxin
LPB401_RS06725 (LPB401_06720)	1571982..1572179	-	198	WP_006887478.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LPB401_RS06730 (LPB401_06725)	1572246..1572980	-	735	WP_023134147.1	class I SAM-dependent methyltransferase	-
LPB401_RS06735 (LPB401_06730)	1572977..1573438	-	462	WP_051344433.1	DUF2867 domain-containing protein	-
LPB401_RS06740 (LPB401_06735)	1573549..1573776	-	228	WP_006887491.1	YdeI/OmpD-associated family protein	-
LPB401_RS06745 (LPB401_06740)	1574080..1574940	-	861	WP_231375419.1	protein RtoA (Ratio-A)	-
LPB401_RS06750 (LPB401_06745)	1575253..1575465	+	213	WP_023134152.1	TOBE domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-40)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 14031.24 Da
• Isoelectric Point: 5.9114

>T210157 WP_023134146.1 NZ_CP079819:c1571985-1571617 [Rothia aeria]
MILVDTNVWVDHLHHAEPELSELLIRDEICCHDLVLTELALGSLKKRDEFLSALSELKRLPLVDDHEVRWFIEKRKLWGR
GLSAVDVHLLASVVVVPGTTLWTRDKRLRDVAQDLGCRFENG

Nucleotide

• Length: 369 bp

>T210157 NZ_CP104442:c2579940-2579837 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7097.14 Da
• Isoelectric Point: 7.0120

>AT210157 WP_006887478.1 NZ_CP079819:c1572179-1571982 [Rothia aeria]
MRTTVTLDEEIVAKAVKLTGIEERSVLVREAMETLVRIENGRLLAALGGSDPQAQAAPRHRNVQS

Nucleotide

• Length: 198 bp

>AT210157 NZ_CP104442:2579799-2580070 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Toxin

• AlphaFold DB: U7V465

Antitoxin

• AlphaFold DB: I0UV86