Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4565548..4566347 | Replicon | chromosome |
| Accession | NC_005126 | ||
| Organism | Photorhabdus luminescens subsp. laumondii TTO1 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | Q7N0J4 |
| Locus tag | PLU_RS19295 | Protein ID | WP_011148028.1 |
| Coordinates | 4565823..4566347 (+) | Length | 175 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | Q7N0J5 |
| Locus tag | PLU_RS19290 | Protein ID | WP_011148027.1 |
| Coordinates | 4565548..4565826 (+) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PLU_RS19275 (plu3885) | 4561768..4562046 | + | 279 | WP_011148023.1 | exodeoxyribonuclease VII small subunit | - |
| PLU_RS19280 (plu3886) | 4562051..4562968 | + | 918 | WP_011148024.1 | (2E,6E)-farnesyl diphosphate synthase | - |
| PLU_RS19285 (plu3887) | 4563031..4564896 | + | 1866 | WP_011148025.1 | 1-deoxy-D-xylulose-5-phosphate synthase | - |
| PLU_RS19290 (plu3889) | 4565548..4565826 | + | 279 | WP_011148027.1 | DUF1778 domain-containing protein | Antitoxin |
| PLU_RS19295 (plu3890) | 4565823..4566347 | + | 525 | WP_011148028.1 | N-acetyltransferase | Toxin |
| PLU_RS19300 | 4566488..4567257 | + | 770 | Protein_3846 | IS982 family transposase | - |
| PLU_RS19305 | 4567423..4567745 | - | 323 | Protein_3847 | type II toxin-antitoxin system YafQ family toxin | - |
| PLU_RS19310 (plu3894) | 4567717..4567989 | - | 273 | WP_011148029.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| PLU_RS19315 (plu3895) | 4568269..4568760 | - | 492 | WP_011148030.1 | phosphatidylglycerophosphatase A | - |
| PLU_RS19320 (plu3896) | 4568753..4569742 | - | 990 | WP_011148031.1 | thiamine-phosphate kinase | - |
| PLU_RS19325 (plu3897) | 4569843..4570259 | - | 417 | WP_011148032.1 | transcription antitermination factor NusB | - |
| PLU_RS19330 (plu3898) | 4570286..4570756 | - | 471 | WP_011148033.1 | 6,7-dimethyl-8-ribityllumazine synthase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 175 a.a. Molecular weight: 18864.82 Da Isoelectric Point: 9.3787
>T21015 WP_011148028.1 NC_005126:4565823-4566347 [Photorhabdus laumondii subsp. laumondii TTO1]
MMLPIWHEEPIGKHHDRGAFDCGDEALNQFLHRHARQSHEKGGAKTYLAVSKNNGTVLGYYSLSPASIAYERAPEVIKRG
LARHEVPVFRLGRLAIDLSVQSQGLGGQLLLAAGRRCLLVAAQAGGVALLIDAKNERVAEWYASYGAIPLLDAHLSLLLP
FKTIHAALVTAGKL
MMLPIWHEEPIGKHHDRGAFDCGDEALNQFLHRHARQSHEKGGAKTYLAVSKNNGTVLGYYSLSPASIAYERAPEVIKRG
LARHEVPVFRLGRLAIDLSVQSQGLGGQLLLAAGRRCLLVAAQAGGVALLIDAKNERVAEWYASYGAIPLLDAHLSLLLP
FKTIHAALVTAGKL
Download Length: 525 bp
>T21015 NC_005126:4565823-4566347 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGATGCTACCAATCTGGCACGAAGAACCTATAGGCAAACATCATGATCGTGGTGCTTTTGACTGTGGTGATGAGGCGTT
GAATCAGTTTTTACATCGCCATGCAAGGCAGAGCCATGAGAAAGGTGGGGCAAAAACCTACCTTGCAGTTAGCAAGAACA
ATGGAACGGTATTAGGTTACTACAGTCTAAGTCCCGCTTCTATTGCTTATGAACGTGCACCGGAAGTGATTAAACGTGGT
CTGGCTCGACATGAAGTGCCAGTATTTCGGCTTGGCCGTCTGGCTATAGATCTTTCAGTACAGAGTCAAGGACTCGGTGG
TCAGTTGTTGCTAGCCGCTGGTCGGCGCTGTTTATTGGTGGCCGCACAGGCTGGCGGGGTTGCATTGCTGATTGATGCCA
AGAATGAGCGTGTTGCCGAGTGGTACGCCAGCTATGGTGCTATTCCGCTATTAGATGCCCACCTATCTTTGCTGTTACCA
TTCAAAACAATACATGCAGCTCTAGTCACTGCGGGGAAGCTTTAA
ATGATGCTACCAATCTGGCACGAAGAACCTATAGGCAAACATCATGATCGTGGTGCTTTTGACTGTGGTGATGAGGCGTT
GAATCAGTTTTTACATCGCCATGCAAGGCAGAGCCATGAGAAAGGTGGGGCAAAAACCTACCTTGCAGTTAGCAAGAACA
ATGGAACGGTATTAGGTTACTACAGTCTAAGTCCCGCTTCTATTGCTTATGAACGTGCACCGGAAGTGATTAAACGTGGT
CTGGCTCGACATGAAGTGCCAGTATTTCGGCTTGGCCGTCTGGCTATAGATCTTTCAGTACAGAGTCAAGGACTCGGTGG
TCAGTTGTTGCTAGCCGCTGGTCGGCGCTGTTTATTGGTGGCCGCACAGGCTGGCGGGGTTGCATTGCTGATTGATGCCA
AGAATGAGCGTGTTGCCGAGTGGTACGCCAGCTATGGTGCTATTCCGCTATTAGATGCCCACCTATCTTTGCTGTTACCA
TTCAAAACAATACATGCAGCTCTAGTCACTGCGGGGAAGCTTTAA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10343.93 Da Isoelectric Point: 5.1133
>AT21015 WP_011148027.1 NC_005126:4565548-4565826 [Photorhabdus laumondii subsp. laumondii TTO1]
MPQIPVETNDRMSLRIASEEKSLLMRAAALQHTNLTEFVLRNVMPAARKVIDENERLELTERDSLHVLDLLDNPPAPNDK
LLAAAFALPKQS
MPQIPVETNDRMSLRIASEEKSLLMRAAALQHTNLTEFVLRNVMPAARKVIDENERLELTERDSLHVLDLLDNPPAPNDK
LLAAAFALPKQS
Download Length: 279 bp
>AT21015 NC_005126:4565548-4565826 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGCCTCAGATCCCAGTAGAAACTAACGACCGAATGTCGCTACGTATTGCCTCAGAAGAAAAGTCGCTGTTGATGCGTGC
AGCCGCTTTACAACATACCAACTTGACTGAGTTCGTGCTCCGCAATGTGATGCCAGCAGCACGGAAAGTTATCGACGAGA
ACGAACGGCTGGAGCTGACCGAAAGAGATAGTTTGCATGTTCTGGATCTTTTGGATAACCCACCGGCACCCAATGATAAA
TTGTTGGCCGCAGCATTTGCCTTGCCGAAACAATCATGA
ATGCCTCAGATCCCAGTAGAAACTAACGACCGAATGTCGCTACGTATTGCCTCAGAAGAAAAGTCGCTGTTGATGCGTGC
AGCCGCTTTACAACATACCAACTTGACTGAGTTCGTGCTCCGCAATGTGATGCCAGCAGCACGGAAAGTTATCGACGAGA
ACGAACGGCTGGAGCTGACCGAAAGAGATAGTTTGCATGTTCTGGATCTTTTGGATAACCCACCGGCACCCAATGATAAA
TTGTTGGCCGCAGCATTTGCCTTGCCGAAACAATCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6L9JMG1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6L9JLN0 |