Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4188321..4188984 Replicon chromosome
Accession NC_005126
Organism Photorhabdus luminescens subsp. laumondii TTO1

Toxin (Protein)


Gene name cptA Uniprot ID Q7N1C2
Locus tag PLU_RS17630 Protein ID WP_011147734.1
Coordinates 4188321..4188737 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q7N1C1
Locus tag PLU_RS17635 Protein ID WP_011147735.1
Coordinates 4188718..4188984 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PLU_RS17610 (plu3550) 4184298..4186031 - 1734 WP_011147730.1 single-stranded-DNA-specific exonuclease RecJ -
PLU_RS17615 (plu3551) 4186031..4186738 - 708 WP_011147731.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PLU_RS17620 (plu3552) 4186762..4187673 - 912 WP_011147732.1 site-specific tyrosine recombinase XerD -
PLU_RS17625 (plu3553) 4187781..4188299 + 519 WP_041380273.1 flavodoxin FldB -
PLU_RS17630 (plu3554) 4188321..4188737 - 417 WP_011147734.1 protein YgfX Toxin
PLU_RS17635 (plu3555) 4188718..4188984 - 267 WP_011147735.1 FAD assembly factor SdhE Antitoxin
PLU_RS17640 (plu3556) 4189162..4190151 + 990 WP_011147736.1 tRNA-modifying protein YgfZ -
PLU_RS17645 (plu3557) 4190163..4190768 + 606 WP_011147737.1 HD domain-containing protein -
PLU_RS17650 (plu3558) 4191700..4193004 - 1305 WP_011147738.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-135)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16363.34 Da        Isoelectric Point: 10.1464

>T21014 WP_011147734.1 NC_005126:c4188737-4188321 [Photorhabdus laumondii subsp. laumondii TTO1]
VVLWKCDLRVSWHTQLISTCVHGAIALIVLFAPWPADDAIFWIFWLPLVLLIIASWGRSQKNIRKSQGLLVLLSDNKLQW
KKHEWQIIRRPWLCRYGVLITAQSFYNQKKIRLWVASDGMPQDEWRNINQLLLQYPDI

Download         Length: 417 bp

>T21014 NC_005126:c4188737-4188321 [Photorhabdus laumondii subsp. laumondii TTO1]
GTGGTCCTGTGGAAGTGTGATCTCAGGGTATCTTGGCATACCCAGCTAATTTCTACCTGTGTTCATGGTGCAATAGCGCT
TATCGTACTATTTGCTCCGTGGCCTGCGGATGACGCTATTTTCTGGATTTTCTGGCTTCCTTTGGTACTGTTGATTATTG
CCAGTTGGGGGCGTAGCCAGAAAAATATCCGTAAATCTCAAGGGCTTTTAGTTCTTCTCAGTGATAATAAGTTGCAATGG
AAGAAGCATGAGTGGCAAATTATCCGGCGGCCGTGGTTGTGTCGTTATGGCGTATTAATTACGGCTCAATCTTTTTATAA
CCAGAAAAAAATCCGTTTATGGGTCGCATCCGATGGTATGCCACAGGATGAATGGAGGAATATTAATCAACTGTTGTTGC
AATATCCTGATATCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10645.25 Da        Isoelectric Point: 5.7258

>AT21014 WP_011147735.1 NC_005126:c4188984-4188718 [Photorhabdus laumondii subsp. laumondii TTO1]
MDIDNKARIHWACRRGMRELDISIMPFFKYEYDSLSDDDKRLFIRLLACADPDLFNWLMNHGRPEDEELFRMIKLIQNRN
KDRGPVEV

Download         Length: 267 bp

>AT21014 NC_005126:c4188984-4188718 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGGATATTGATAATAAAGCGCGTATTCATTGGGCATGTCGGCGTGGAATGCGTGAGCTGGATATTTCAATTATGCCGTT
TTTTAAGTATGAATATGACTCACTCAGTGATGATGATAAACGACTTTTTATTCGCTTACTTGCATGTGCTGATCCTGATC
TATTCAACTGGCTAATGAATCATGGGCGTCCAGAAGATGAAGAGTTATTTCGCATGATTAAACTTATTCAGAATAGAAAT
AAAGATCGTGGTCCTGTGGAAGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JK22

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JKF1

References