Detailed information of TA system TA210137

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 790962..791619
• Replicon: chromosome
• Accession: NZ_CP079807
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain WRC02_S465MC

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: KWL80_RS03930
• Protein ID: WP_040245400.1
• Coordinates: 791209..791619 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: KWL80_RS03925
• Protein ID: WP_002916312.1
• Coordinates: 790962..791228 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KWL80_RS03900 (786118)	786118..787551	-	1434	WP_002916322.1	6-phospho-beta-glucosidase BglA	-
KWL80_RS03905 (787670)	787670..788398	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
KWL80_RS03910 (788448)	788448..788759	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
KWL80_RS03915 (788923)	788923..789582	+	660	WP_048334397.1	hemolysin III family protein	-
KWL80_RS03920 (789733)	789733..790716	-	984	WP_032430613.1	tRNA-modifying protein YgfZ	-
KWL80_RS03925 (790962)	790962..791228	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
KWL80_RS03930 (791209)	791209..791619	+	411	WP_040245400.1	protein YgfX	Toxin
KWL80_RS03935 (791626)	791626..792147	-	522	WP_002916308.1	flavodoxin FldB	-
KWL80_RS03940 (792248)	792248..793144	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
KWL80_RS03945 (793167)	793167..793880	+	714	WP_048290928.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
KWL80_RS03950 (793886)	793886..795619	+	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16035.83 Da
• Isoelectric Point: 11.4778

>T210137 WP_040245400.1 NZ_CP079807:791209-791619 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDSRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T210137 NZ_CP104406:c75867-75343 [Enterobacter hormaechei subsp. steigerwaltii]
GTGGCCAACCTGACCATTGAGATGTTTTCAGAAGAGGCTGTATATGATTTCTCATGCTTCGACTGCGGAGAAACGTCTCT
CAATGATTTTCTTAACAATCGCCTCGCCCAGCAACACAGCGGGCGTATATTACGCGGATATCTGCTTCTGACGAGAGATC
CGATACCGAAAGTGATGGGGTTTTACACGTTGTCCGGGAGCTGCTTTGCAAGAAACACGCTTCCTTCCAACACTCAACAG
CGTAAAGTCCCCTATTCCGACGCCCCAAGCGTTACGCTCGGTCGTCTGGCAATAGACAAAAGTATCCAGCGACAAGGGTA
TGGGGAAACGCTGGTGGCACATGCGATGAAAGTGGTATACCGGGCTTCCCTGGCCGTTGGGATCTACGCTTTGTTTGTTG
ACGCCAAAAATGAGAATGCGATGCGGTTTTATAAGCAGTTAGGCTTTACCCCTCTTACGGGTGATAACGCCAATTCGCTG
TTCTATCCCACAAAAGGCATTGAGAAGTTGTTTGGTGGAAAATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT210137 WP_002916312.1 NZ_CP079807:790962-791228 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT210137 NZ_CP104406:c76140-75871 [Enterobacter hormaechei subsp. steigerwaltii]
ATGTCAGCACTGAAAAAACAGCGCATCGATCTCAGATTAACCGACGACGACAAGAGCATGATCGAAGAAGCTGCGGCAAT
GACCAACCAGACAATTACTCAGTTTATGGTTGCCAGTGCCTCTGAACGTGCTGCGGAAGTGATAGAGCAACATCGTCGCC
TGATTCTTAGCGAAGAGTCATGGAATATAGTGATGGATGCCATCAGTAACCCGCCTGCACCGAATGATAGGCTGAAACGA
GCTGCCGAGCGTCTACAAAGCATGGAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41