Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5104306..5104822 Replicon chromosome
Accession NZ_CP079802
Organism Klebsiella variicola strain EMBL-1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KU883_RS24610 Protein ID WP_022065401.1
Coordinates 5104306..5104590 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KU883_RS24615 Protein ID WP_002886901.1
Coordinates 5104580..5104822 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU883_RS24595 (KU883_24580) 5099409..5101064 + 1656 WP_077139002.1 alpha,alpha-phosphotrehalase -
KU883_RS24600 (KU883_24585) 5101450..5103588 + 2139 WP_077139001.1 anaerobic ribonucleoside-triphosphate reductase -
KU883_RS24605 (KU883_24590) 5103838..5104302 + 465 WP_022065402.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KU883_RS24610 (KU883_24595) 5104306..5104590 - 285 WP_022065401.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KU883_RS24615 (KU883_24600) 5104580..5104822 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KU883_RS24620 (KU883_24605) 5104900..5106810 - 1911 WP_032731805.1 PRD domain-containing protein -
KU883_RS24625 (KU883_24610) 5106833..5107987 - 1155 WP_012969087.1 lactonase family protein -
KU883_RS24630 (KU883_24615) 5108113..5108853 - 741 WP_022065398.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11128.97 Da        Isoelectric Point: 10.2849

>T210132 WP_022065401.1 NZ_CP079802:c5104590-5104306 [Klebsiella variicola]
MTYELEFDPRAWREWQMPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T210132 NZ_CP104405:c2809048-2808945 [Enterobacter hormaechei subsp. steigerwaltii]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT210132 WP_002886901.1 NZ_CP079802:c5104822-5104580 [Klebsiella variicola]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT210132 NZ_CP104405:2808932-2809141 [Enterobacter hormaechei subsp. steigerwaltii]
TTTTCAAGCAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGC
TAAAAGTTGGCATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGTA
AAAGTGGTCTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References