Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 857800..858457 Replicon chromosome
Accession NZ_CP079802
Organism Klebsiella variicola strain EMBL-1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KU883_RS04260 Protein ID WP_002916310.1
Coordinates 858047..858457 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KU883_RS04255 Protein ID WP_002916312.1
Coordinates 857800..858066 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU883_RS04230 (KU883_04230) 852897..854330 - 1434 WP_063105732.1 6-phospho-beta-glucosidase BglA -
KU883_RS04235 (KU883_04235) 854450..855178 - 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
KU883_RS04240 (KU883_04240) 855229..855540 + 312 WP_008806430.1 N(4)-acetylcytidine aminohydrolase -
KU883_RS04245 (KU883_04245) 855704..856363 + 660 WP_008806429.1 hemolysin III family protein -
KU883_RS04250 (KU883_04250) 856571..857554 - 984 WP_032733797.1 tRNA-modifying protein YgfZ -
KU883_RS04255 (KU883_04255) 857800..858066 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KU883_RS04260 (KU883_04260) 858047..858457 + 411 WP_002916310.1 protein YgfX Toxin
KU883_RS04265 (KU883_04265) 858464..858985 - 522 WP_008806427.1 flavodoxin FldB -
KU883_RS04270 (KU883_04270) 859086..859982 + 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
KU883_RS04275 (KU883_04275) 860005..860718 + 714 WP_077139430.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KU883_RS04280 (KU883_04280) 860724..862457 + 1734 WP_064166671.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T210117 WP_002916310.1 NZ_CP079802:858047-858457 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T210117 NZ_CP104403:c2929149-2928796 [Enterobacter hormaechei subsp. steigerwaltii]
GTGTGGGCGATTAAAACTACGGACAGGTTTGACGACTGGTTCACCTCATTAAACGATAGCGAGAGAGCCAGCGTACTGGC
CGCGCTACTTGTTTTGCGGGAGAGGGGACCGGGTCTGTCCAGACCGTATGCCGATACGCTGAAAGGCTCCCGCCACAGCA
ACATGAAAGAGTTGCGTATCCAGAGTAAGGGTGATCCGCTGAGGGCATTTTTCGCTTTCGATCCGAACCGTACGGGTATT
GTACTGTGTGCGGGCAATAAGGTCGGTAATGAAAGGCGATTTTACGATGAGATGCTCCTCGTTGCGGATCGGGAATACAC
TCGCTGGCTGAACACATTAAAAGAGAGGAATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT210117 WP_002916312.1 NZ_CP079802:857800-858066 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT210117 NZ_CP104403:c2928791-2928489 [Enterobacter hormaechei subsp. steigerwaltii]
ATGGGCAGAACCCTGGAGCAGCTTATTGCAGATGAAAAACCTGAGGTTGTTGCCAGCGCACAGGCAATGGCAACGGATAT
TTTGCTCAATATCCATCTGGCCGAGTTACGTGAAAAAGTGCAAAAAACGCAGGTAGATATGGCCAGGGCGTTGGGTATTA
AACAACCTACTGTCGCCGTCATGGAAAAGGCAGGACGCGATATTAAGCTTTCTTCTTTGAAACGCTACGTTGAGGCCGCC
GGAGGGAAGCTACGGCTGGATGTAGAACTACCCGATGGTTCTCATTACGAGTTTGTGTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References