Detailed information of TA system TA210114

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2608865..2609423
• Replicon: chromosome
• Accession: NZ_CP079801
• Organism: Halopseudomonas sp. RR6

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HV822_RS12000
• Protein ID: WP_238870292.1
• Coordinates: 2609133..2609423 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HV822_RS11995
• Protein ID: WP_238870290.1
• Coordinates: 2608865..2609140 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV822_RS11970 (HV822_11950)	2603884..2605425	+	1542	WP_238870281.1	2-isopropylmalate synthase	-
HV822_RS11975 (HV822_11955)	2605425..2606195	+	771	WP_238870283.1	energy transducer TonB	-
HV822_RS11980 (HV822_11960)	2606192..2606644	+	453	WP_238870285.1	ribosomal protein S18-alanine N-acetyltransferase	-
HV822_RS11985 (HV822_11965)	2606667..2607566	+	900	WP_238870287.1	DMT family transporter	-
HV822_RS11990 (HV822_11970)	2607563..2608561	+	999	WP_238870289.1	isocitrate/isopropylmalate family dehydrogenase	-
HV822_RS11995 (HV822_11975)	2608865..2609140	+	276	WP_238870290.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HV822_RS12000 (HV822_11980)	2609133..2609423	+	291	WP_238870292.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HV822_RS12005 (HV822_11985)	2609841..2610593	+	753	WP_238870294.1	hypothetical protein	-
HV822_RS12010 (HV822_11990)	2610580..2611326	+	747	WP_238870296.1	DEAD/DEAH box helicase	-
HV822_RS12015 (HV822_11995)	2611419..2612459	+	1041	WP_238870298.1	IS481 family transposase	-
HV822_RS12020 (HV822_12000)	2612641..2614074	+	1434	WP_238870300.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2611419..2612459	1040

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11301.19 Da
• Isoelectric Point: 10.6484

>T210114 WP_238870292.1 NZ_CP079801:2609133-2609423 [Halopseudomonas sp. RR6]
VSDFSLEFNQKALKEWHKLDATIRLQFARKLKERMQAPHVEADRLRSLPDCYKIKLRSAGYRLVYQVIDQRLVITVIAVG
KRERSAVYGDAEKRLR

Nucleotide

• Length: 291 bp

>T210114 NZ_CP104403:1744597-1745118 [Enterobacter hormaechei subsp. steigerwaltii]
GTGGCAAATCTCACGATCGAAATGTTATCAGAGGGAACCGATTACGATTTCGGCGATTTCGATTGTGGTGAACCCTCGCT
AAATGCCTTCCTTACCGAGCACCTGATACGTCAGCACGGCGGGCGTATTTTACGCGGCTACCTGCTTAAAGAACGCGACC
ATCCGCGTGTCCTGGGCTATTACACACTCTCGGGAAGTTGCTTTGAAAAAGTGATGCTTCCTTCAAAGACTCAGCAGCGC
CGCATCCCATACAGCAACGTCCCCAGCGTGACGCTGGGGCGTCTGGCTGTCCATAAAGAACTCCAGGGAAACGAGTGGGG
AACAACGCTTGTCACACACGCTATGCGCGTTGTTTATCTGGCCTCGCAGGCTGTTGGCGTCCACGGAATTTTTGTGGATG
CGCTTAACGAACGGGCCAAACGATTTTATCTGAAGCTGGGGTTTATCCCGCTGGCAGGTGAAAACAGCAGTTCGCTGTTC
TTCCCCACGCAATCTATAGAACGACTGTTTGAGCAGGCGTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 9837.32 Da
• Isoelectric Point: 4.2457

>AT210114 WP_238870290.1 NZ_CP079801:2608865-2609140 [Halopseudomonas sp. RR6]
MAFQILAEVAASVTDLKRDPMGTLREGHGKPVVILNRNEPAFYAVPAKLYEAMLEQLDDIKLEELVRSRMGEPTVAVDID
DLIADAGGAGV

Nucleotide

• Length: 276 bp

>AT210114 NZ_CP104403:1744321-1744590 [Enterobacter hormaechei subsp. steigerwaltii]
ATGCCAGCACTCAAAAAACAGCGTATCGATCTTCGCCTGTCGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACCAACCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCCGAAGTCATCGAACAGCATCGGCGTC
TCGTATTAAACGAAGCCTCATGGATTGCCGTTATGGATGCCATCGACAATCCGCCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCGAAACGTCTTCGAAACATGGAGTGA