Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VagC |
Location | 48403..49025 | Replicon | plasmid pAJ_082-3 |
Accession | NZ_CP079794 | ||
Organism | Acinetobacter johnsonii strain AJ_082 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A7H8SKU4 |
Locus tag | EGT72_RS17585 | Protein ID | WP_063454755.1 |
Coordinates | 48630..49025 (+) | Length | 132 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | R9B9I8 |
Locus tag | EGT72_RS17580 | Protein ID | WP_000401521.1 |
Coordinates | 48403..48633 (+) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EGT72_RS17550 (EGT72_017550) | 44099..44434 | + | 336 | WP_035363642.1 | hypothetical protein | - |
EGT72_RS17555 (EGT72_017555) | 44484..44663 | + | 180 | WP_016658770.1 | hypothetical protein | - |
EGT72_RS17560 (EGT72_017560) | 44660..45046 | + | 387 | WP_004769969.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
EGT72_RS17565 (EGT72_017565) | 45048..45599 | - | 552 | WP_016658769.1 | macro domain-containing protein | - |
EGT72_RS17570 (EGT72_017570) | 45605..46288 | - | 684 | WP_016658768.1 | hypothetical protein | - |
EGT72_RS17575 (EGT72_017575) | 46498..47823 | + | 1326 | Protein_56 | ISNCY family transposase | - |
EGT72_RS17580 (EGT72_017580) | 48403..48633 | + | 231 | WP_000401521.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
EGT72_RS17585 (EGT72_017585) | 48630..49025 | + | 396 | WP_063454755.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
EGT72_RS17590 (EGT72_017590) | 49186..49617 | + | 432 | WP_063454756.1 | hypothetical protein | - |
EGT72_RS17595 (EGT72_017595) | 49739..50338 | - | 600 | Protein_60 | ISNCY family transposase | - |
EGT72_RS17605 (EGT72_017605) | 51618..52358 | - | 741 | Protein_62 | ISNCY-like element ISAba32 family transposase | - |
EGT72_RS17610 (EGT72_017610) | 52566..53518 | + | 953 | Protein_63 | IS5 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..155957 | 155957 | |
- | inside | IScluster/Tn | - | - | 41753..59330 | 17577 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14897.23 Da Isoelectric Point: 7.1633
>T210112 WP_063454755.1 NZ_CP079794:48630-49025 [Acinetobacter johnsonii]
MIYLLDTNICIYVINNKPQQVFERFKQYQLGQLAISSITASELAFGVEKSGSERNKKALNKFLSPLEILPYDEQAIWHYA
KLRQNLQSTGKPIGSLDMLIAAHALALDVVLVTNNTKEFERIDGLKLENWV
MIYLLDTNICIYVINNKPQQVFERFKQYQLGQLAISSITASELAFGVEKSGSERNKKALNKFLSPLEILPYDEQAIWHYA
KLRQNLQSTGKPIGSLDMLIAAHALALDVVLVTNNTKEFERIDGLKLENWV
Download Length: 396 bp
>T210112 NZ_CP104403:c1118389-1118171 [Enterobacter hormaechei subsp. steigerwaltii]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTTGAACGAGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAGC
TGACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTGTGGAAATTTGTTCGTTAA
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTTGAACGAGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAGC
TGACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTGTGGAAATTTGTTCGTTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8759.04 Da Isoelectric Point: 4.7708
>AT210112 WP_000401521.1 NZ_CP079794:48403-48633 [Acinetobacter johnsonii]
MEIAKVFQTGRSQAVRLPKAFRFNGTEVAIKSFGRGVLLMPIDNPWDVMLEAINEFEVGFQLERADQGEQLREEFR
MEIAKVFQTGRSQAVRLPKAFRFNGTEVAIKSFGRGVLLMPIDNPWDVMLEAINEFEVGFQLERADQGEQLREEFR
Download Length: 231 bp
>AT210112 NZ_CP104403:c1118791-1118417 [Enterobacter hormaechei subsp. steigerwaltii]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7H8SKU4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2N6V6E6 |