Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-StbC |
| Location | 3561555..3562210 | Replicon | chromosome |
| Accession | NC_005126 | ||
| Organism | Photorhabdus luminescens subsp. laumondii TTO1 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | Q7N2L9 |
| Locus tag | PLU_RS15215 | Protein ID | WP_011147274.1 |
| Coordinates | 3561555..3561974 (-) | Length | 140 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | Q7N2L8 |
| Locus tag | PLU_RS15220 | Protein ID | WP_011147275.1 |
| Coordinates | 3561971..3562210 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PLU_RS15190 (plu3052) | 3556573..3558864 | + | 2292 | WP_011147269.1 | ribonucleoside-diphosphate reductase subunit alpha | - |
| PLU_RS15195 (plu3053) | 3558877..3560007 | + | 1131 | WP_011147270.1 | ribonucleotide-diphosphate reductase subunit beta | - |
| PLU_RS15200 (plu3054) | 3560007..3560273 | + | 267 | WP_011147271.1 | 2Fe-2S ferredoxin-like protein | - |
| PLU_RS15205 (plu3055) | 3560395..3560775 | - | 381 | WP_011147272.1 | type II toxin-antitoxin system YafO family toxin | - |
| PLU_RS15210 (plu3056) | 3560775..3561395 | - | 621 | WP_041380171.1 | hypothetical protein | - |
| PLU_RS15215 (plu3057) | 3561555..3561974 | - | 420 | WP_011147274.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| PLU_RS15220 (plu3058) | 3561971..3562210 | - | 240 | WP_011147275.1 | Arc family DNA-binding protein | Antitoxin |
| PLU_RS15225 | 3562540..3563553 | + | 1014 | WP_041380173.1 | Gfo/Idh/MocA family oxidoreductase | - |
| PLU_RS15230 (plu3059) | 3563795..3564301 | - | 507 | WP_011147276.1 | CdiI family contact-dependent growth inhibition immunity protein | - |
| PLU_RS15235 (plu3060) | 3564465..3564971 | - | 507 | WP_011147277.1 | CdiI family contact-dependent growth inhibition immunity protein | - |
| PLU_RS15240 (plu3061) | 3565135..3565635 | - | 501 | WP_011147278.1 | CdiI family contact-dependent growth inhibition immunity protein | - |
| PLU_RS15245 (plu3062) | 3565635..3565979 | - | 345 | WP_011147279.1 | hypothetical protein | - |
| PLU_RS15250 (plu3063) | 3566206..3566739 | - | 534 | WP_162096541.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 14785.05 Da Isoelectric Point: 6.4726
>T21011 WP_011147274.1 NC_005126:c3561974-3561555 [Photorhabdus laumondii subsp. laumondii TTO1]
MILLDTNVVSEPLRLSGHPAVVAWIDEQNVETLYLAAISLAELRFGVAALSNGKRKDTLHRNLERSVVPLFTGRILPFDA
AASEAYAEIMARAKSEGKAIGKADGYIAAIAAANGLIVATRDISPFEAAGLTVINPWKG
MILLDTNVVSEPLRLSGHPAVVAWIDEQNVETLYLAAISLAELRFGVAALSNGKRKDTLHRNLERSVVPLFTGRILPFDA
AASEAYAEIMARAKSEGKAIGKADGYIAAIAAANGLIVATRDISPFEAAGLTVINPWKG
Download Length: 420 bp
>T21011 NC_005126:c3561974-3561555 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGATACTGCTAGATACGAACGTGGTTTCCGAGCCACTGCGGCTCAGCGGCCACCCCGCTGTGGTTGCCTGGATAGATGA
ACAGAATGTCGAGACGCTTTACTTGGCAGCGATCAGCTTGGCTGAGCTTCGCTTTGGGGTTGCAGCGCTGTCCAATGGTA
AGCGCAAAGATACCCTGCATAGAAACCTAGAGCGGAGTGTTGTTCCTTTATTTACCGGTCGTATCTTGCCATTCGATGCG
GCCGCTTCGGAAGCTTATGCCGAGATCATGGCGCGAGCGAAGAGCGAGGGGAAAGCCATTGGGAAGGCTGACGGGTATAT
TGCGGCTATTGCAGCGGCGAATGGGCTGATTGTTGCAACCCGCGACATATCACCTTTTGAAGCTGCCGGGCTTACTGTTA
TCAACCCTTGGAAGGGCTAA
ATGATACTGCTAGATACGAACGTGGTTTCCGAGCCACTGCGGCTCAGCGGCCACCCCGCTGTGGTTGCCTGGATAGATGA
ACAGAATGTCGAGACGCTTTACTTGGCAGCGATCAGCTTGGCTGAGCTTCGCTTTGGGGTTGCAGCGCTGTCCAATGGTA
AGCGCAAAGATACCCTGCATAGAAACCTAGAGCGGAGTGTTGTTCCTTTATTTACCGGTCGTATCTTGCCATTCGATGCG
GCCGCTTCGGAAGCTTATGCCGAGATCATGGCGCGAGCGAAGAGCGAGGGGAAAGCCATTGGGAAGGCTGACGGGTATAT
TGCGGCTATTGCAGCGGCGAATGGGCTGATTGTTGCAACCCGCGACATATCACCTTTTGAAGCTGCCGGGCTTACTGTTA
TCAACCCTTGGAAGGGCTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 8776.01 Da Isoelectric Point: 5.7268
>AT21011 WP_011147275.1 NC_005126:c3562210-3561971 [Photorhabdus laumondii subsp. laumondii TTO1]
MPSITVRNVPDEVHRALRVRAATHGRSAEAEIRFILENAVQPEGRIKLGSLLAKIGREAEGVDLEIERDKTPAEPMSFE
MPSITVRNVPDEVHRALRVRAATHGRSAEAEIRFILENAVQPEGRIKLGSLLAKIGREAEGVDLEIERDKTPAEPMSFE
Download Length: 240 bp
>AT21011 NC_005126:c3562210-3561971 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGCCATCCATTACTGTCAGAAATGTACCGGACGAAGTGCATCGTGCCTTGCGGGTACGCGCAGCCACACATGGCCGTAG
TGCTGAGGCCGAAATCCGGTTTATTCTGGAAAACGCCGTACAACCGGAGGGGCGCATCAAGCTGGGTTCCTTGCTGGCAA
AAATCGGCCGCGAGGCGGAGGGCGTCGATCTTGAGATCGAGCGTGATAAGACACCTGCTGAGCCGATGAGTTTTGAATGA
ATGCCATCCATTACTGTCAGAAATGTACCGGACGAAGTGCATCGTGCCTTGCGGGTACGCGCAGCCACACATGGCCGTAG
TGCTGAGGCCGAAATCCGGTTTATTCTGGAAAACGCCGTACAACCGGAGGGGCGCATCAAGCTGGGTTCCTTGCTGGCAA
AAATCGGCCGCGAGGCGGAGGGCGTCGATCTTGAGATCGAGCGTGATAAGACACCTGCTGAGCCGATGAGTTTTGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6L9JKK2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6L9JKY2 |