Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 22781..23306 | Replicon | plasmid pKPT698-tetA |
| Accession | NZ_CP079782 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain T698-1 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | J5VBT8 |
| Locus tag | KYY07_RS26095 | Protein ID | WP_004197633.1 |
| Coordinates | 22781..23086 (-) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | A0A9E1GDP8 |
| Locus tag | KYY07_RS26100 | Protein ID | WP_004197642.1 |
| Coordinates | 23088..23306 (-) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KYY07_RS26060 (KYY07_26005) | 18360..19340 | - | 981 | WP_014386491.1 | IS5-like element ISKpn26 family transposase | - |
| KYY07_RS26065 (KYY07_26010) | 19443..19556 | + | 114 | WP_014343462.1 | hypothetical protein | - |
| KYY07_RS26070 (KYY07_26015) | 19685..19942 | + | 258 | WP_241510519.1 | hypothetical protein | - |
| KYY07_RS26075 (KYY07_26020) | 20000..20779 | - | 780 | WP_023287113.1 | site-specific integrase | - |
| KYY07_RS26080 (KYY07_26025) | 20977..21993 | - | 1017 | WP_009309921.1 | hypothetical protein | - |
| KYY07_RS26085 (KYY07_26030) | 22027..22362 | - | 336 | WP_009309920.1 | hypothetical protein | - |
| KYY07_RS26090 (KYY07_26035) | 22412..22723 | - | 312 | WP_009309919.1 | hypothetical protein | - |
| KYY07_RS26095 (KYY07_26040) | 22781..23086 | - | 306 | WP_004197633.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| KYY07_RS26100 (KYY07_26045) | 23088..23306 | - | 219 | WP_004197642.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| KYY07_RS26105 (KYY07_26050) | 23906..24136 | + | 231 | WP_001261276.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| KYY07_RS26110 (KYY07_26055) | 24133..24549 | + | 417 | WP_000754566.1 | type II toxin-antitoxin system VapC family toxin | - |
| KYY07_RS26115 (KYY07_26060) | 24590..25468 | - | 879 | WP_009309916.1 | restriction endonuclease | - |
| KYY07_RS26120 (KYY07_26065) | 26130..27407 | + | 1278 | WP_009309915.1 | HlyD family secretion protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | aac(6')-Ib-cr / ARR-3 / dfrA27 / aadA16 / qacE / sul1 / catA2 / tet(A) | mrkA / mrkB / mrkC / mrkD / mrkF / mrkJ | 1..138834 | 138834 | |
| - | flank | IS/Tn | - | - | 18360..19340 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11585.27 Da Isoelectric Point: 6.4661
>T210100 WP_004197633.1 NZ_CP079782:c23086-22781 [Klebsiella pneumoniae subsp. pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDDSYRLMTTDMASVTASVTGEEV
ADLSHRENDIKNAINLMFWGI
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDDSYRLMTTDMASVTASVTGEEV
ADLSHRENDIKNAINLMFWGI
Download Length: 306 bp
>T210100 NZ_CP104401:c2393534-2393049 [Enterobacter hormaechei subsp. steigerwaltii]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATACCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTCAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATACCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTCAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG
Antitoxin
Download Length: 73 a.a. Molecular weight: 8376.34 Da Isoelectric Point: 4.7405
>AT210100 WP_004197642.1 NZ_CP079782:c23306-23088 [Klebsiella pneumoniae subsp. pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRAERWQAENQEGMAEVARFIEMNGSFADENRDW
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRAERWQAENQEGMAEVARFIEMNGSFADENRDW
Download Length: 219 bp
>AT210100 NZ_CP104401:c2393788-2393522 [Enterobacter hormaechei subsp. steigerwaltii]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCGCAGTGGGACGTGTAA
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCGCAGTGGGACGTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|