Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4705774..4706290 Replicon chromosome
Accession NZ_CP079781
Organism Klebsiella pneumoniae subsp. pneumoniae strain T698-1

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag KYY07_RS23290 Protein ID WP_002886902.1
Coordinates 4705774..4706058 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KYY07_RS23295 Protein ID WP_002886901.1
Coordinates 4706048..4706290 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYY07_RS23265 (KYY07_23205) 4701258..4701521 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
KYY07_RS23270 (KYY07_23210) 4701651..4701824 + 174 WP_002886906.1 hypothetical protein -
KYY07_RS23275 (KYY07_23215) 4701827..4702570 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KYY07_RS23280 (KYY07_23220) 4702927..4705065 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
KYY07_RS23285 (KYY07_23225) 4705306..4705770 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KYY07_RS23290 (KYY07_23230) 4705774..4706058 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KYY07_RS23295 (KYY07_23235) 4706048..4706290 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KYY07_RS23300 (KYY07_23240) 4706368..4708278 - 1911 WP_241510471.1 PRD domain-containing protein -
KYY07_RS23305 (KYY07_23245) 4708301..4709455 - 1155 WP_002886900.1 lactonase family protein -
KYY07_RS23310 (KYY07_23250) 4709521..4710261 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T210097 WP_002886902.1 NZ_CP079781:c4706058-4705774 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T210097 NZ_CP104401:c1147125-1146907 [Enterobacter hormaechei subsp. steigerwaltii]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTTGAACGAGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAGC
TGACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTGTGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT210097 WP_002886901.1 NZ_CP079781:c4706290-4706048 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT210097 NZ_CP104401:c1147527-1147153 [Enterobacter hormaechei subsp. steigerwaltii]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References