Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3990991..3991610 Replicon chromosome
Accession NZ_CP079781
Organism Klebsiella pneumoniae subsp. pneumoniae strain T698-1

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KYY07_RS19865 Protein ID WP_002892050.1
Coordinates 3991392..3991610 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KYY07_RS19860 Protein ID WP_002892066.1
Coordinates 3990991..3991365 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYY07_RS19850 (KYY07_19800) 3986143..3987336 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KYY07_RS19855 (KYY07_19805) 3987359..3990505 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
KYY07_RS19860 (KYY07_19810) 3990991..3991365 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KYY07_RS19865 (KYY07_19815) 3991392..3991610 + 219 WP_002892050.1 HHA domain-containing protein Toxin
KYY07_RS19870 (KYY07_19820) 3991769..3992335 + 567 WP_002892030.1 maltose O-acetyltransferase -
KYY07_RS19875 (KYY07_19825) 3992307..3992447 - 141 WP_004147370.1 hypothetical protein -
KYY07_RS19880 (KYY07_19830) 3992468..3992938 + 471 WP_002892026.1 YlaC family protein -
KYY07_RS19885 (KYY07_19835) 3992913..3994364 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
KYY07_RS19890 (KYY07_19840) 3994465..3995163 + 699 WP_002892021.1 GNAT family protein -
KYY07_RS19895 (KYY07_19845) 3995160..3995300 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KYY07_RS19900 (KYY07_19850) 3995300..3995563 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T210095 WP_002892050.1 NZ_CP079781:3991392-3991610 [Klebsiella pneumoniae subsp. pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T210095 NZ_CP104401:631269-631646 [Enterobacter hormaechei subsp. steigerwaltii]
ATGCAAACCCAATCTATACACCCTGTACGGGCGACGGCGTCACGCCCATCTCCTGTCGATATCTGGCAAACCCTGTTGAC
GTACCTCCTGGAGCAACATTACGGGCTCACACTTAACGACACCCCGTTTGGCAACGACAGGGTGATCCAGGAGCATATTG
AGGCTGGTATCTCACTGTGCGATGGCGTCAATTTTATCGTCGAAAAGTACGAACTGGTCCGTATCGATCGTCACGGTTTC
AGCACAGAAACACAGTCACCGCTTATTGGCAGCATCGATATCCTTCGTGCACGAAAAGCGACCGGGCTGATGACCCGCAA
CGATTACAAAGTGGTCACCGACATCACCACCGGCAAATACAGCGGGGGGACACGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT210095 WP_002892066.1 NZ_CP079781:3990991-3991365 [Klebsiella pneumoniae subsp. pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT210095 NZ_CP104401:630847-631206 [Enterobacter hormaechei subsp. steigerwaltii]
ATGCCAGACATCAACACCACCCAAAATGACAATATGGATGCACCGAGCTGGGGCCTGCATCGCGATATCACACCGTGTTT
TGGCGCACGACTGGTGCAGGAAGGCAACTGCCTGCATTACCTGGCTGACCGCGCCAGCATCACCGGTCAATTCAGCGAGG
CGGATTTGCGCCATCTGGATCAGGTTTTTCCGCTGATGCTCAAACAGCTTGAGTTGATGTTGGTATCCGGTGAGCTCAAC
CCACGCCACCAGCACTGCGTCACGTTGTATTACAATGGTCTCATCTGCGAAGCGGACACACTGGGCAGTTGTGGTTATAT
CTACCTCGCGATTTATCCGGGGGAACCGCCAGCAGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References