Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 2612545..2614133 | Replicon | chromosome |
| Accession | NZ_CP079781 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain T698-1 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | A0A0H3GN97 |
| Locus tag | KYY07_RS12930 | Protein ID | WP_004199851.1 |
| Coordinates | 2612545..2613867 (-) | Length | 441 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A0H3GXD8 |
| Locus tag | KYY07_RS12935 | Protein ID | WP_002904790.1 |
| Coordinates | 2613867..2614133 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KYY07_RS12915 (KYY07_12885) | 2607610..2610111 | + | 2502 | WP_241510514.1 | fimbria/pilus outer membrane usher protein | - |
| KYY07_RS12920 (KYY07_12890) | 2610099..2611103 | + | 1005 | WP_004199852.1 | fimbrial protein | - |
| KYY07_RS12925 (KYY07_12895) | 2611236..2612528 | + | 1293 | WP_002904794.1 | glycoside hydrolase family 10 protein | - |
| KYY07_RS12930 (KYY07_12900) | 2612545..2613867 | - | 1323 | WP_004199851.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| KYY07_RS12935 (KYY07_12905) | 2613867..2614133 | - | 267 | WP_002904790.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
| KYY07_RS12940 (KYY07_12910) | 2614399..2614725 | - | 327 | WP_002904788.1 | hydroxyisourate hydrolase | - |
| KYY07_RS12945 (KYY07_12915) | 2614722..2615222 | - | 501 | WP_002904787.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
| KYY07_RS12950 (KYY07_12920) | 2615200..2616579 | - | 1380 | WP_004199850.1 | nucleobase:cation symporter-2 family protein | - |
| KYY07_RS12955 (KYY07_12925) | 2616925..2618079 | + | 1155 | WP_002904783.1 | FAD-dependent urate hydroxylase HpxO | - |
| KYY07_RS12960 (KYY07_12930) | 2618060..2618983 | - | 924 | WP_004199849.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49128.44 Da Isoelectric Point: 7.2487
>T210094 WP_004199851.1 NZ_CP079781:c2613867-2612545 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
>T210094 NZ_CP104401:c368249-368070 [Enterobacter hormaechei subsp. steigerwaltii]
ATGGATAGCAGGAATGCAATAGCAATGATAGAAGCCGATGGGTGGTATCTGGTGAGAGTTAAAGGCAGTCATCATCAGTT
CAAACACCCAACGAAAAAGGGGCTGGTAACGGTAAAGCATCCACAGAAAGACATACCGTTACCAACACTGAAAAGCATCA
AAAAACAGGCGGGGCTCTAA
ATGGATAGCAGGAATGCAATAGCAATGATAGAAGCCGATGGGTGGTATCTGGTGAGAGTTAAAGGCAGTCATCATCAGTT
CAAACACCCAACGAAAAAGGGGCTGGTAACGGTAAAGCATCCACAGAAAGACATACCGTTACCAACACTGAAAAGCATCA
AAAAACAGGCGGGGCTCTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9906.27 Da Isoelectric Point: 8.5912
>AT210094 WP_002904790.1 NZ_CP079781:c2614133-2613867 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW
Download Length: 267 bp
>AT210094 NZ_CP104401:c368048-367638 [Enterobacter hormaechei subsp. steigerwaltii]
ATGTTGTACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCTGATATTCCTGGCTGCTTCTCTGG
CGGTGATGATTATCAGGACGCGATTGAAAGCGTACGTGAAGCGATCGAGGCACACATCGAATTACTGGTTGAAGATGGCG
AGAGCGTTCCAGAAGCAACGACCGTCGAAAACTGGCTTTCTGATCCAGAGTACGCCGGTGCGGTATGGGCCCTGGTTGAC
GTGGATATAACTCGTCTGATGGGAAAAGCGGAAAAAATCAATGTGACGCTTCCTTCACTGCTGATCCGACGTATCGATCA
GTTTGTGGCCGCCCATCCTGAATACGGTAGCCGGTCTGGCTTCCTGTCTCGTGTCGCGGCAGATAAAGTAATTGGACGAG
AAAAACGATAA
ATGTTGTACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCTGATATTCCTGGCTGCTTCTCTGG
CGGTGATGATTATCAGGACGCGATTGAAAGCGTACGTGAAGCGATCGAGGCACACATCGAATTACTGGTTGAAGATGGCG
AGAGCGTTCCAGAAGCAACGACCGTCGAAAACTGGCTTTCTGATCCAGAGTACGCCGGTGCGGTATGGGCCCTGGTTGAC
GTGGATATAACTCGTCTGATGGGAAAAGCGGAAAAAATCAATGTGACGCTTCCTTCACTGCTGATCCGACGTATCGATCA
GTTTGTGGCCGCCCATCCTGAATACGGTAGCCGGTCTGGCTTCCTGTCTCGTGTCGCGGCAGATAAAGTAATTGGACGAG
AAAAACGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GN97 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GXD8 |