Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 868274..868931 Replicon chromosome
Accession NZ_CP079781
Organism Klebsiella pneumoniae subsp. pneumoniae strain T698-1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KYY07_RS04385 Protein ID WP_002916310.1
Coordinates 868521..868931 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KYY07_RS04380 Protein ID WP_002916312.1
Coordinates 868274..868540 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYY07_RS04355 (KYY07_04355) 863430..864863 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
KYY07_RS04360 (KYY07_04360) 864982..865710 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KYY07_RS04365 (KYY07_04365) 865760..866071 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
KYY07_RS04370 (KYY07_04370) 866235..866894 + 660 WP_002916317.1 hemolysin III family protein -
KYY07_RS04375 (KYY07_04375) 867045..868028 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KYY07_RS04380 (KYY07_04380) 868274..868540 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KYY07_RS04385 (KYY07_04385) 868521..868931 + 411 WP_002916310.1 protein YgfX Toxin
KYY07_RS04390 (KYY07_04390) 868938..869459 - 522 WP_002916308.1 flavodoxin FldB -
KYY07_RS04395 (KYY07_04395) 869560..870456 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KYY07_RS04400 (KYY07_04400) 870479..871192 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KYY07_RS04405 (KYY07_04405) 871198..872931 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T210085 WP_002916310.1 NZ_CP079781:868521-868931 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T210085 NZ_CP104387:c1007568-1006219 [Cupriavidus gilardii]
ATGGGACGGCGATCCCACACCCGTACGCTGACGCTTTGGATGAACGGCGCGTTCGTCGGCACCTGGCATTTCAGTCCGCG
TGCCGGCGATGTGCTGCAGTACGCGCCGGAGTGGGTGGCCTCCGGCGCCGGGCGGCCCTTGTCCCTGTCGCTGCCTTTCA
CTCCGGGCAACGCGCCGCATCGTGGCGACAAGGTGCGGGCCTACTTCGACAATCTGTTGCCGGATACCCGGGAGATTCGT
GAGCGCATTGCCCGGCGGTATCGCACCGGTTCGACCGATGCCTTCGACCTGCTCGCCGAAATCGGCCGCGATTGCGTGGG
CGCGCTGCAACTATTGCCGGACGGCACCGTGCCTGAAGGTGTGCAGCCGGTCGCGGCGGAACCGCTGACCGAGGCTCAGG
TCGCGCAGGTGCTGCGCGGCACGCTGCGATCCGCGCCGCCGGGCTTCGTGGACGAGCAGGACGAGTTCCGTATCTCCATC
GCCGGCGCCCAGGAAAAGACCGCGCTGCTGTACGACAACGGCGCCTGGTGCCTGCCGCACGGCCAAACGCCGACCACCCA
CATCCTGAAGCTGCCGCTTGGCCTCGTCGGCGGGCTGAAGCTGAACATGACCGAATCGGTCGAGAACGAGTGGCTGTGCT
CGCTGATCCTGCGCCAGTTCGGCCTGCCGGTCGCGCACTGCGAACCGGTGCAGTTCGAGGACCTGAAGGCGCTCAGCGTG
CAGCGGTTCGACCGCATGTGGTGGCAAAGTCCGGACGGCGATCGTCGCCTCGTTCGGCTGCCGCAGGAGGACATGTGCCA
GGCCAAGGGCGTGCCGCCGGCGTTCAAGTACGAAGCCGATGGCGGACCCGGCATCGACAGCATCATGGAAACGCTGGCCG
GGTCGACGACGCGCGACGAAGACCGCCGAACGTTCTTCCAGGCACAGGTCCTGTTCTGGATGCTGCGGGCCACCGATGGC
CACGCGAAGAACTTCAGCCTGTTCCTGCGCCCGGAGGGCCGGTATCAGTTGACGCCACTCTACGACGTGCTCTCGGCATA
CCCGATCATCGGGGAGGCGCCGGGCAAGTTGTCGCCGTTCCGGGTCAAGATGGCGATGGCCGTTCGGACGCGAAACGCGC
ACTACCAGATGCGGGAAATCCAGCGCCGCCATTGGCTCGCCGTCGGCGAGCGGCATGGCGTGATCACCGCGGACGGACGT
CCCGCACGGTACGTGCTCGACGATCTGGCCGAACGCGCGCCGCGGGTGGCACAGGCGATACGGGAAGCGCTGCCGAAGAG
CTTCCCGGAGCCGCTGGCCGACTGCATTCTCGATGGAATGCTGGCCGAGGCGGAAAGGCTGGCCGGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT210085 WP_002916312.1 NZ_CP079781:868274-868540 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT210085 NZ_CP104387:c1007834-1007571 [Cupriavidus gilardii]
ATGAGCAACTTCACCGTCCGCACCGCCGAGCAACTGCCGCAACTGCTGCAGGCCTTTCGCAAGGAGGCGGGCCTGACGCA
GGCCGAGGCGGCGTTGCGCATGGGAGTCAGCCAACAGACCTTGTCCGCGCTGGAACGCAATCCGGCGCGGGTCAGCGTCG
ACAAGCTGATGCGCGTGCTCAGCGTTCTCGGCGTCGAACTCGTGCTGCACAAGCCGGCTCCCCAACCGCATAACGGCGCG
TCCTCCAGCCCGCAGGTCTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References