Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 701183..701709 | Replicon | chromosome |
| Accession | NZ_CP079780 | ||
| Organism | Escherichia coli strain BL12 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | KYX59_RS05455 | Protein ID | WP_000323025.1 |
| Coordinates | 701183..701470 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | KYX59_RS05460 | Protein ID | WP_000534858.1 |
| Coordinates | 701470..701709 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KYX59_RS05405 (696207) | 696207..696422 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| KYX59_RS05410 (696642) | 696642..696812 | + | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| KYX59_RS05415 (697176) | 697176..697391 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| KYX59_RS05420 (697692) | 697692..697904 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| KYX59_RS05425 (697959) | 697959..698048 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| KYX59_RS05430 (698326) | 698326..699078 | - | 753 | WP_001047135.1 | antitermination protein | - |
| KYX59_RS05435 (699092) | 699092..700141 | - | 1050 | WP_259482664.1 | DUF968 domain-containing protein | - |
| KYX59_RS05440 (700143) | 700143..700421 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| KYX59_RS05445 (700488) | 700488..700739 | - | 252 | WP_000980994.1 | protein Rem | - |
| KYX59_RS05450 (700956) | 700956..701111 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| KYX59_RS05455 (701183) | 701183..701470 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| KYX59_RS05460 (701470) | 701470..701709 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| KYX59_RS05465 (701734) | 701734..702039 | + | 306 | WP_001326990.1 | protein YdfV | - |
| KYX59_RS05470 (702242) | 702242..702574 | + | 333 | WP_001317460.1 | FlxA-like family protein | - |
| KYX59_RS05475 (703011) | 703011..703160 | - | 150 | WP_011443592.1 | protein YdfW | - |
| KYX59_RS05480 (703281) | 703281..704330 | - | 1050 | Protein_696 | ISNCY family transposase | - |
| KYX59_RS05485 (705120) | 705120..705405 | - | 286 | Protein_697 | hypothetical protein | - |
| KYX59_RS05490 (705883) | 705883..706372 | - | 490 | Protein_698 | class I SAM-dependent methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 662342..716054 | 53712 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T210061 WP_000323025.1 NZ_CP079780:c701470-701183 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T210061 NZ_CP104384:647861-648175 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT210061 WP_000534858.1 NZ_CP079780:c701709-701470 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT210061 NZ_CP104384:648172-648588 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|