Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/- |
| Location | 11061..11653 | Replicon | plasmid pBL12EC-4 |
| Accession | NZ_CP079779 | ||
| Organism | Escherichia coli strain BL12 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | V0AGQ2 |
| Locus tag | KYX59_RS01800 | Protein ID | WP_000520549.1 |
| Coordinates | 11405..11653 (-) | Length | 83 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | V0AWG0 |
| Locus tag | KYX59_RS01795 | Protein ID | WP_000681613.1 |
| Coordinates | 11061..11408 (-) | Length | 116 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KYX59_RS01765 (KYX59_01715) | 7066..7392 | - | 327 | WP_000008647.1 | TrbC/VirB2 family protein | - |
| KYX59_RS01770 (KYX59_01720) | 7406..8026 | - | 621 | WP_000157549.1 | lytic transglycosylase domain-containing protein | - |
| KYX59_RS01775 (KYX59_01725) | 8382..8597 | - | 216 | WP_000760375.1 | EexN family lipoprotein | - |
| KYX59_RS01780 (KYX59_01730) | 8594..8887 | - | 294 | WP_000134733.1 | sigma factor-like helix-turn-helix DNA-binding protein | - |
| KYX59_RS01785 (KYX59_01735) | 8964..10193 | - | 1230 | WP_001329504.1 | DNA relaxase/nickase TaxC | - |
| KYX59_RS01790 (KYX59_01740) | 10197..10700 | - | 504 | WP_000781813.1 | relaxosome-coupling protein TaxA | - |
| KYX59_RS01795 (KYX59_01745) | 11061..11408 | - | 348 | WP_000681613.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| KYX59_RS01800 (KYX59_01750) | 11405..11653 | - | 249 | WP_000520549.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| KYX59_RS01805 (KYX59_01755) | 11958..12308 | - | 351 | WP_000854259.1 | hypothetical protein | - |
| KYX59_RS01810 (KYX59_01760) | 12399..12698 | - | 300 | WP_000650309.1 | hypothetical protein | - |
| KYX59_RS01815 (KYX59_01765) | 13152..13379 | - | 228 | WP_000801440.1 | hypothetical protein | - |
| KYX59_RS01820 (KYX59_01770) | 13366..13617 | - | 252 | WP_001230707.1 | hypothetical protein | - |
| KYX59_RS01825 (KYX59_01775) | 13614..14156 | - | 543 | WP_001083906.1 | hypothetical protein | - |
| KYX59_RS01830 (KYX59_01780) | 14261..14776 | - | 516 | WP_001025395.1 | J domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | mcr-1.1 | - | 1..37819 | 37819 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 83 a.a. Molecular weight: 9422.08 Da Isoelectric Point: 10.4800
>T210053 WP_000520549.1 NZ_CP079779:c11653-11405 [Escherichia coli]
MGKTDKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
LL
MGKTDKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
LL
Download Length: 249 bp
>T210053 NZ_CP104373:c4706491-4705958 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTATTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTATTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
Antitoxin
Download Length: 116 a.a. Molecular weight: 13113.84 Da Isoelectric Point: 4.6723
>AT210053 WP_000681613.1 NZ_CP079779:c11408-11061 [Escherichia coli]
MKHLKYKGYLGTVEPDFENNVLYGKLAFIRDLVTYEASTLAELEQEFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSNHRAGA
MKHLKYKGYLGTVEPDFENNVLYGKLAFIRDLVTYEASTLAELEQEFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSNHRAGA
Download Length: 348 bp
>AT210053 NZ_CP104373:c4706768-4706502 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829CIX3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829CLC1 |