Detailed information of TA system TA021005

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2706247..2706797
• Replicon: chromosome
• Accession: NC_005126
• Organism: Photorhabdus luminescens subsp. laumondii TTO1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q7N4M0
• Locus tag: PLU_RS11505
• Protein ID: WP_011146553.1
• Coordinates: 2706507..2706797 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q7N4M1
• Locus tag: PLU_RS11500
• Protein ID: WP_011146552.1
• Coordinates: 2706247..2706519 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PLU_RS11480 (plu2300)	2701463..2702944	-	1482	WP_011146548.1	type VI secretion system contractile sheath large subunit	-
PLU_RS11485 (plu2301)	2702952..2703503	-	552	WP_011146549.1	type VI secretion system contractile sheath small subunit	-
PLU_RS11490 (plu2302)	2704228..2704482	+	255	WP_011146550.1	hypothetical protein	-
PLU_RS11495 (plu2303)	2704727..2705602	-	876	WP_011146551.1	phage tail protein	-
PLU_RS11500 (plu2305)	2706247..2706519	+	273	WP_011146552.1	CopG family ribbon-helix-helix protein	Antitoxin
PLU_RS11505 (plu2306)	2706507..2706797	+	291	WP_011146553.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PLU_RS26035	2707022..2707198	+	177	Protein_2279	IS1595 family transposase	-
PLU_RS11515 (plu2308)	2707235..2707513	-	279	WP_011146554.1	putative addiction module antidote protein	-
PLU_RS11520 (plu2309)	2707510..2707812	-	303	WP_011146555.1	type II toxin-antitoxin system RelE/ParE family toxin	-
PLU_RS25340 (plu2311)	2707910..2708050	+	141	WP_082302859.1	recombinase family protein	-
PLU_RS27160	2708043..2708231	-	189	Protein_2283	helix-turn-helix domain-containing protein	-
PLU_RS26690 (plu2312)	2708221..2708310	-	90	Protein_2284	class A beta-lactamase	-
PLU_RS11525 (plu2313)	2709005..2710858	+	1854	WP_011146556.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-40)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10867.56 Da
• Isoelectric Point: 10.0918

>T21005 WP_011146553.1 NC_005126:2706507-2706797 [Photorhabdus laumondii subsp. laumondii TTO1]
MPRLIWSPPALADIQRLYGFLAKKDKDTARRAIKTIRAGVKMLARQPEAGRPADDMDPAFREWLIDFGSSGYIALYRIEG
ETATIFAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T21005 NC_005126:2706507-2706797 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGCCACGTTTGATTTGGTCTCCGCCTGCTCTCGCTGATATACAGCGGCTCTATGGTTTTCTTGCTAAAAAAGACAAAGA
CACTGCTCGTCGAGCTATTAAAACAATACGTGCTGGCGTGAAAATGCTGGCACGTCAGCCTGAAGCAGGACGCCCTGCTG
ACGATATGGATCCGGCATTCCGAGAATGGCTTATTGATTTTGGAAGTAGTGGCTATATCGCCTTGTATCGGATTGAGGGT
GAAACAGCAACAATTTTTGCTGTACGGCATCAAAAAGAGGCCGGATATTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10654.87 Da
• Isoelectric Point: 4.6704

>AT21005 WP_011146552.1 NC_005126:2706247-2706519 [Photorhabdus laumondii subsp. laumondii TTO1]
MATSVKLDDNLKSRIQYLAEVRHRSAHWIMREAIRDYVEREEKRESFKQDALRAWEAYQENGLHLTLEEADDWLAKLEAG
EDAELPECHV

Nucleotide

• Length: 273 bp

>AT21005 NC_005126:2706247-2706519 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGGCAACCTCAGTAAAACTTGACGATAACTTGAAAAGCCGGATCCAGTATTTGGCAGAAGTGCGACATCGTTCAGCTCA
TTGGATAATGCGTGAAGCTATACGTGACTATGTAGAGCGCGAGGAAAAGCGTGAATCTTTCAAACAGGATGCATTGCGTG
CTTGGGAAGCGTATCAAGAGAATGGACTACACCTGACGCTTGAAGAAGCGGACGACTGGTTAGCTAAGCTCGAAGCAGGA
GAAGATGCGGAGTTACCTGAATGCCACGTTTGA

Structures

Toxin

• AlphaFold DB: A0A6L9JTC2

Antitoxin

• AlphaFold DB: A0A6L9JNK5