Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 88147..88682 Replicon plasmid pBL12EC-2
Accession NZ_CP079777
Organism Escherichia coli strain BL12

Toxin (Protein)


Gene name relE Uniprot ID A0A0K4CX11
Locus tag KYX59_RS01090 Protein ID WP_000222771.1
Coordinates 88395..88682 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T1PXV2
Locus tag KYX59_RS01085 Protein ID WP_001139206.1
Coordinates 88147..88398 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYX59_RS01075 (KYX59_01065) 83176..83616 - 441 WP_023352064.1 hypothetical protein -
KYX59_RS01080 (KYX59_01070) 83650..87564 - 3915 Protein_94 helicase-related protein -
KYX59_RS01085 (KYX59_01075) 88147..88398 + 252 WP_001139206.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KYX59_RS01090 (KYX59_01080) 88395..88682 + 288 WP_000222771.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KYX59_RS01095 89050..89163 - 114 Protein_97 alkaline phosphatase -
KYX59_RS01100 (KYX59_01090) 89162..89370 + 209 Protein_98 hypothetical protein -
KYX59_RS01105 (KYX59_01095) 89404..90101 + 698 WP_223411729.1 IS1 family transposase -
KYX59_RS01110 90200..90280 - 81 Protein_100 hypothetical protein -
KYX59_RS01115 (KYX59_01100) 90279..90446 + 168 Protein_101 IS3 family transposase -
KYX59_RS01120 (KYX59_01105) 90789..91127 - 339 WP_223656872.1 hypothetical protein -
KYX59_RS01125 (KYX59_01110) 91130..91660 - 531 WP_001352021.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid tet(A) / qnrS1 / dfrA14 / blaTEM-1C / floR - 1..119769 119769
- flank IS/Tn - - 89598..90101 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11116.17 Da        Isoelectric Point: 10.5833

>T210048 WP_000222771.1 NZ_CP079777:88395-88682 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKTIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYHLASERMK

Download         Length: 288 bp

>T210048 NZ_CP104373:777448-777858 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9171.39 Da        Isoelectric Point: 4.0927

>AT210048 WP_001139206.1 NZ_CP079777:88147-88398 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYL

Download         Length: 252 bp

>AT210048 NZ_CP104373:777201-777467 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4CX11

Antitoxin

Source ID Structure
AlphaFold DB T1PXV2

References