Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 41153..41754 Replicon plasmid pBL12EC-2
Accession NZ_CP079777
Organism Escherichia coli strain BL12

Toxin (Protein)


Gene name doc Uniprot ID A0A838AVV6
Locus tag KYX59_RS00825 Protein ID WP_063501799.1
Coordinates 41374..41754 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag KYX59_RS00820 Protein ID WP_001190712.1
Coordinates 41153..41374 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYX59_RS00795 (KYX59_00790) 36270..36947 + 678 WP_001354545.1 metallophosphoesterase -
KYX59_RS00800 (KYX59_00795) 36944..37657 + 714 WP_063501794.1 hypothetical protein -
KYX59_RS00810 (KYX59_00805) 38794..39417 - 624 Protein_40 restriction endonuclease subunit S -
KYX59_RS00815 (KYX59_00810) 39414..40970 - 1557 WP_088213504.1 type I restriction-modification system subunit M -
KYX59_RS00820 (KYX59_00815) 41153..41374 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KYX59_RS00825 (KYX59_00820) 41374..41754 + 381 WP_063501799.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KYX59_RS00830 41759..41938 + 180 WP_001411052.1 hypothetical protein -
KYX59_RS00835 (KYX59_00825) 41966..43009 + 1044 WP_088213502.1 DUF968 domain-containing protein -
KYX59_RS00840 (KYX59_00830) 43263..43484 + 222 WP_001361625.1 host cell division inhibitor Icd-like protein -
KYX59_RS00845 (KYX59_00835) 43481..44599 + 1119 Protein_47 phage antirepressor KilAC domain-containing protein -
KYX59_RS00850 (KYX59_00840) 44632..45483 - 852 WP_000611656.1 phage repressor protein C1 -
KYX59_RS00855 (KYX59_00845) 45594..45803 - 210 WP_063501801.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid tet(A) / qnrS1 / dfrA14 / blaTEM-1C / floR - 1..119769 119769


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13616.39 Da        Isoelectric Point: 5.6343

>T210047 WP_063501799.1 NZ_CP079777:41374-41754 [Escherichia coli]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVVYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGTATGEISVSTVAATLRRLYGSAE

Download         Length: 381 bp

>T210047 NZ_CP104373:711526-712011 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTAATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCGCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT210047 WP_001190712.1 NZ_CP079777:41153-41374 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp

>AT210047 NZ_CP104373:711236-711529 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A838AVV6

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References