Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3052504..3053339 Replicon chromosome
Accession NZ_CP079772
Organism Escherichia coli strain GS04

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7W4PV54
Locus tag KYX57_RS15110 Protein ID WP_000854821.1
Coordinates 3052962..3053339 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag KYX57_RS15105 Protein ID WP_032216526.1
Coordinates 3052504..3052872 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYX57_RS15065 (3047627) 3047627..3048511 + 885 WP_032216515.1 50S ribosome-binding GTPase -
KYX57_RS15070 (3048630) 3048630..3049307 + 678 WP_259481943.1 hypothetical protein -
KYX57_RS15075 (3049313) 3049313..3049546 + 234 WP_001278282.1 DUF905 family protein -
KYX57_RS15080 (3049645) 3049645..3050463 + 819 WP_053902307.1 DUF932 domain-containing protein -
KYX57_RS15085 (3050555) 3050555..3051040 + 486 WP_165467258.1 antirestriction protein -
KYX57_RS15090 (3051056) 3051056..3051532 + 477 WP_001186724.1 RadC family protein -
KYX57_RS15095 (3051601) 3051601..3051822 + 222 WP_001601167.1 DUF987 domain-containing protein -
KYX57_RS15100 (3051841) 3051841..3052485 + 645 Protein_2953 antitoxin of toxin-antitoxin stability system -
KYX57_RS15105 (3052504) 3052504..3052872 + 369 WP_032216526.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KYX57_RS15110 (3052962) 3052962..3053339 + 378 WP_000854821.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
KYX57_RS15115 (3053336) 3053336..3053485 + 150 Protein_2956 DUF5983 family protein -
KYX57_RS15120 (3053561) 3053561..3053758 + 198 WP_023563519.1 DUF957 domain-containing protein -
KYX57_RS15125 (3053843) 3053843..3054685 + 843 WP_001529559.1 DUF4942 domain-containing protein -
KYX57_RS15135 (3056211) 3056211..3057749 + 1539 WP_001187177.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3029252..3065562 36310
- flank IS/Tn - - 3055201..3055578 377


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13930.95 Da        Isoelectric Point: 8.5163

>T210031 WP_000854821.1 NZ_CP079772:3052962-3053339 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T210031 NZ_CP104371:857124-857231 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13810.69 Da        Isoelectric Point: 6.2066

>AT210031 WP_032216526.1 NZ_CP079772:3052504-3052872 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLLCTVTPCFGARLVQEGNRLHYLVDRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT210031 NZ_CP104371:c857074-857011 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W4PV54

Antitoxin

Source ID Structure

References