Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2939208..2939803 Replicon chromosome
Accession NZ_CP079772
Organism Escherichia coli strain GS04

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag KYX57_RS14490 Protein ID WP_000239579.1
Coordinates 2939208..2939558 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag KYX57_RS14495 Protein ID WP_001223208.1
Coordinates 2939552..2939803 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYX57_RS14470 (2934654) 2934654..2935676 - 1023 WP_001313531.1 ABC transporter permease -
KYX57_RS14475 (2935690) 2935690..2937192 - 1503 WP_021557471.1 sugar ABC transporter ATP-binding protein -
KYX57_RS14480 (2937332) 2937332..2938288 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
KYX57_RS14485 (2938598) 2938598..2939128 + 531 WP_000055072.1 inorganic diphosphatase -
KYX57_RS14490 (2939208) 2939208..2939558 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
KYX57_RS14495 (2939552) 2939552..2939803 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
KYX57_RS14500 (2940016) 2940016..2940357 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
KYX57_RS14505 (2940360) 2940360..2944139 - 3780 WP_097503546.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T210030 WP_000239579.1 NZ_CP079772:c2939558-2939208 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T210030 NZ_CP104371:856589-856696 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT210030 WP_001223208.1 NZ_CP079772:c2939803-2939552 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT210030 NZ_CP104371:c856536-856475 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References