Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2336507..2337125 Replicon chromosome
Accession NZ_CP079772
Organism Escherichia coli strain GS04

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag KYX57_RS11675 Protein ID WP_001291435.1
Coordinates 2336907..2337125 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag KYX57_RS11670 Protein ID WP_000344800.1
Coordinates 2336507..2336881 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYX57_RS11660 (2331596) 2331596..2332789 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KYX57_RS11665 (2332812) 2332812..2335961 + 3150 WP_218077447.1 efflux RND transporter permease AcrB -
KYX57_RS11670 (2336507) 2336507..2336881 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
KYX57_RS11675 (2336907) 2336907..2337125 + 219 WP_001291435.1 HHA domain-containing protein Toxin
KYX57_RS11680 (2337297) 2337297..2337848 + 552 WP_000102564.1 maltose O-acetyltransferase -
KYX57_RS11685 (2337964) 2337964..2338434 + 471 WP_000136192.1 YlaC family protein -
KYX57_RS11690 (2338598) 2338598..2340148 + 1551 WP_023281027.1 cyclic-guanylate-specific phosphodiesterase PdeB -
KYX57_RS11695 (2340190) 2340190..2340543 - 354 WP_000878140.1 DUF1428 domain-containing protein -
KYX57_RS11705 (2340922) 2340922..2341233 + 312 WP_000409911.1 MGMT family protein -
KYX57_RS11710 (2341264) 2341264..2341836 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T210027 WP_001291435.1 NZ_CP079772:2336907-2337125 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T210027 NZ_CP104371:274968-275071 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT210027 WP_000344800.1 NZ_CP079772:2336507-2336881 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT210027 NZ_CP104371:c275109-274841 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References