Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2662395..2662930 Replicon chromosome
Accession NC_005126
Organism Photorhabdus luminescens subsp. laumondii TTO1

Toxin (Protein)


Gene name relE Uniprot ID Q7N4Q8
Locus tag PLU_RS11300 Protein ID WP_011146513.1
Coordinates 2662395..2662682 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q7N4Q7
Locus tag PLU_RS11305 Protein ID WP_011146514.1
Coordinates 2662679..2662930 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PLU_RS11290 (plu2262) 2657678..2661124 - 3447 WP_011146511.1 molybdopterin-dependent oxidoreductase -
PLU_RS24560 (plu2263) 2661328..2662239 - 912 WP_011146512.1 hypothetical protein -
PLU_RS11300 (plu2264) 2662395..2662682 - 288 WP_011146513.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PLU_RS11305 (plu2265) 2662679..2662930 - 252 WP_011146514.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PLU_RS11310 (plu2266) 2663260..2664180 + 921 WP_011146515.1 alpha/beta hydrolase -
PLU_RS11315 (plu2267) 2664517..2665560 - 1044 WP_125043766.1 hypothetical protein -
PLU_RS11320 (plu2268) 2666118..2666579 + 462 WP_011146517.1 helix-turn-helix domain-containing protein -
PLU_RS11325 (plu2269) 2666798..2667088 - 291 WP_011146518.1 type II toxin-antitoxin system RelE/ParE family toxin -
PLU_RS11330 (plu2270) 2667085..2667363 - 279 WP_011146519.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11154.35 Da        Isoelectric Point: 10.5828

>T21002 WP_011146513.1 NC_005126:c2662682-2662395 [Photorhabdus laumondii subsp. laumondii TTO1]
MIYRVKFTEDALKEWKRLDKSVQQQFAKKLKKCCVEPHIPSVKLRGMPNCYKIKLRASGFRLVYEVIDNVLIIVVVAVGK
RERSEAYELASKRLR

Download         Length: 288 bp

>T21002 NC_005126:c2662682-2662395 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGATCTATAGAGTGAAATTCACGGAAGATGCACTCAAGGAGTGGAAGAGACTTGATAAATCAGTCCAACAACAATTTGC
TAAGAAGCTGAAAAAGTGCTGTGTTGAACCTCATATTCCATCAGTTAAACTTCGAGGCATGCCGAATTGTTACAAAATAA
AATTACGCGCTTCTGGTTTTCGCTTAGTTTATGAGGTCATAGATAATGTGTTGATTATCGTCGTAGTAGCAGTTGGTAAG
CGCGAACGGAGTGAAGCGTATGAGCTAGCAAGTAAGAGACTAAGATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9221.57 Da        Isoelectric Point: 4.0233

>AT21002 WP_011146514.1 NC_005126:c2662930-2662679 [Photorhabdus laumondii subsp. laumondii TTO1]
MANIILSDISASISELKKNPMATLSAGAGYPIAILNRNQPVFYCIPAELYEQILDALDDQELIRLVNERRGQALVDVDLD
NYL

Download         Length: 252 bp

>AT21002 NC_005126:c2662930-2662679 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGGCCAACATAATTCTGTCAGATATTAGCGCAAGCATTAGTGAACTTAAAAAGAACCCTATGGCGACCCTTAGTGCCGG
GGCTGGATACCCTATTGCAATCCTAAATCGTAACCAACCCGTGTTTTATTGTATTCCTGCGGAGCTCTATGAACAGATAC
TTGATGCTTTGGACGATCAAGAGCTTATTCGACTGGTAAATGAGCGTAGAGGGCAGGCATTGGTTGATGTAGATTTGGAT
AATTATCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JQJ5

References