Detailed information of TA system TA210013

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4305526..4306180
• Replicon: chromosome
• Accession: NZ_CP079770
• Organism: Escherichia coli strain HL15

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: S1EEB2
• Locus tag: KYX58_RS22765
• Protein ID: WP_000244777.1
• Coordinates: 4305773..4306180 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: KYX58_RS22760
• Protein ID: WP_029392880.1
• Coordinates: 4305526..4305792 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KYX58_RS22735 (4300695)	4300695..4301438	+	744	WP_000951964.1	SDR family oxidoreductase	-
KYX58_RS22740 (4301495)	4301495..4302928	-	1434	WP_001336277.1	6-phospho-beta-glucosidase BglA	-
KYX58_RS22745 (4302973)	4302973..4303284	+	312	WP_001182957.1	N(4)-acetylcytidine aminohydrolase	-
KYX58_RS22750 (4303448)	4303448..4304107	+	660	WP_000250274.1	hemolysin III family protein	-
KYX58_RS22755 (4304303)	4304303..4305283	-	981	WP_000886062.1	tRNA-modifying protein YgfZ	-
KYX58_RS22760 (4305526)	4305526..4305792	+	267	WP_029392880.1	FAD assembly factor SdhE	Antitoxin
KYX58_RS22765 (4305773)	4305773..4306180	+	408	WP_000244777.1	protein YgfX	Toxin
KYX58_RS22770 (4306220)	4306220..4306741	-	522	WP_001055874.1	flavodoxin FldB	-
KYX58_RS22775 (4306853)	4306853..4307749	+	897	WP_000806638.1	site-specific tyrosine recombinase XerD	-
KYX58_RS22780 (4307774)	4307774..4308484	+	711	WP_000715214.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
KYX58_RS22785 (4308490)	4308490..4310223	+	1734	WP_000813200.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 16031.96 Da
• Isoelectric Point: 11.5202

>T210013 WP_000244777.1 NZ_CP079770:4305773-4306180 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Nucleotide

• Length: 408 bp

>T210013 NZ_CP104366:c995788-995261 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10520.10 Da
• Isoelectric Point: 5.1599

>AT210013 WP_029392880.1 NZ_CP079770:4305526-4305792 [Escherichia coli]
MDINSKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT210013 NZ_CP104366:c996075-995785 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Structures

Toxin

• AlphaFold DB: A0A7U9LFV7