Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4146268..4147103 | Replicon | chromosome |
| Accession | NZ_CP079770 | ||
| Organism | Escherichia coli strain HL15 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A763DSF8 |
| Locus tag | KYX58_RS21930 | Protein ID | WP_047928871.1 |
| Coordinates | 4146726..4147103 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | KYX58_RS21925 | Protein ID | WP_047928872.1 |
| Coordinates | 4146268..4146636 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KYX58_RS21885 (4141310) | 4141310..4142746 | + | 1437 | Protein_3988 | autotransporter adhesin family protein | - |
| KYX58_RS21890 (4142817) | 4142817..4143050 | + | 234 | WP_047928875.1 | DUF905 family protein | - |
| KYX58_RS21895 (4143141) | 4143141..4143959 | + | 819 | WP_096935434.1 | DUF932 domain-containing protein | - |
| KYX58_RS21900 (4143959) | 4143959..4144228 | + | 270 | WP_259553614.1 | hypothetical protein | - |
| KYX58_RS21905 (4144297) | 4144297..4144770 | + | 474 | WP_001355870.1 | antirestriction protein | - |
| KYX58_RS21910 (4144786) | 4144786..4145262 | + | 477 | WP_001186770.1 | RadC family protein | - |
| KYX58_RS21915 (4145331) | 4145331..4145552 | + | 222 | WP_000692312.1 | DUF987 domain-containing protein | - |
| KYX58_RS21920 (4145571) | 4145571..4146218 | + | 648 | WP_114493062.1 | antitoxin of toxin-antitoxin stability system | - |
| KYX58_RS21925 (4146268) | 4146268..4146636 | + | 369 | WP_047928872.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| KYX58_RS21930 (4146726) | 4146726..4147103 | + | 378 | WP_047928871.1 | TA system toxin CbtA family protein | Toxin |
| KYX58_RS21935 (4147100) | 4147100..4147249 | + | 150 | Protein_3998 | DUF5983 family protein | - |
| KYX58_RS21940 (4147325) | 4147325..4147522 | + | 198 | WP_096093965.1 | DUF957 domain-containing protein | - |
| KYX58_RS21945 (4147607) | 4147607..4148452 | + | 846 | WP_072650597.1 | DUF4942 domain-containing protein | - |
| KYX58_RS21955 (4148752) | 4148752..4149258 | + | 507 | WP_000228937.1 | G/U mismatch-specific DNA glycosylase | - |
| KYX58_RS21960 (4149337) | 4149337..4151178 | - | 1842 | WP_000437375.1 | RNA polymerase sigma factor RpoD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | rfaE | 4136906..4201288 | 64382 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13941.88 Da Isoelectric Point: 7.3222
>T210010 WP_047928871.1 NZ_CP079770:4146726-4147103 [Escherichia coli]
MKTLPVLPGQAAGSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTHSQLINSIDILRARRATGLMTRDNYRTVNGITQGKHPEAKQ
MKTLPVLPGQAAGSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTHSQLINSIDILRARRATGLMTRDNYRTVNGITQGKHPEAKQ
Download Length: 378 bp
>T210010 NZ_CP104366:364853-365128 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13757.47 Da Isoelectric Point: 5.0907
>AT210010 WP_047928872.1 NZ_CP079770:4146268-4146636 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEDNQLHYLADRAGIRGRFSDADAYHLDQALPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEDNQLHYLADRAGIRGRFSDADAYHLDQALPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT210010 NZ_CP104366:364590-364850 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|