Detailed information of TA system TA021001

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE(toxin)
• Location: 2489209..2489740
• Replicon: chromosome
• Accession: NC_005126
• Organism: Photorhabdus luminescens subsp. laumondii TTO1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q7N553
• Locus tag: PLU_RS10515
• Protein ID: WP_011146359.1
• Coordinates: 2489450..2489740 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q7N554
• Locus tag: PLU_RS10510
• Protein ID: WP_011146358.1
• Coordinates: 2489209..2489460 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PLU_RS10480 (plu2097)	2484708..2485271	+	564	WP_011146352.1	VOC family protein	-
PLU_RS10485 (plu2098)	2485287..2485601	-	315	WP_011146353.1	type II toxin-antitoxin system MqsA family antitoxin	-
PLU_RS10490 (plu2099)	2485602..2485937	-	336	WP_011146354.1	hypothetical protein	-
PLU_RS25280 (plu2100)	2485992..2486150	+	159	Protein_2070	VOC family protein	-
PLU_RS10495 (plu2101)	2486288..2487034	+	747	WP_011146355.1	copper homeostasis protein CutC	-
PLU_RS10500 (plu2102)	2487210..2488181	-	972	WP_011146356.1	tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB	-
PLU_RS10505 (plu2103)	2488178..2488936	-	759	WP_011146357.1	carboxy-S-adenosyl-L-methionine synthase CmoA	-
PLU_RS10510 (plu2104)	2489209..2489460	+	252	WP_011146358.1	plasmid stabilization protein	Antitoxin
PLU_RS10515 (plu2105)	2489450..2489740	+	291	WP_011146359.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PLU_RS10520 (plu2106)	2489867..2490262	-	396	WP_011146360.1	MAPEG family protein	-
PLU_RS10525 (plu2107)	2490539..2492311	+	1773	WP_011146361.1	aspartate--tRNA ligase	-
PLU_RS10530 (plu2108)	2492311..2492748	+	438	WP_011146362.1	dihydroneopterin triphosphate diphosphatase	-
PLU_RS10535 (plu2109)	2492778..2493521	+	744	WP_011146363.1	YebC/PmpR family DNA-binding transcriptional regulator	-
PLU_RS10540 (plu2110)	2493753..2494274	+	522	WP_011146364.1	crossover junction endodeoxyribonuclease RuvC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11169.14 Da
• Isoelectric Point: 11.2253

>T21001 WP_011146359.1 NC_005126:2489450-2489740 [Photorhabdus laumondii subsp. laumondii TTO1]
MIYSLQFEKRALKEWKKLGHPIKEQLKRKLAERLENPHVPSARLSGRSNRYKIKLRSSGNRLVYEVNDNKIILLVIAIGK
RGKRVGDAVYTLANER

Nucleotide

• Length: 291 bp

>T21001 NC_005126:2489450-2489740 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGATCTATAGTCTGCAATTTGAAAAGCGGGCCTTAAAAGAGTGGAAGAAGTTAGGTCATCCAATTAAGGAGCAGCTAAA
GAGAAAATTGGCTGAACGCTTAGAAAACCCTCATGTGCCGTCAGCAAGATTAAGTGGGCGATCGAACCGATACAAAATTA
AATTGCGGTCTTCTGGCAACCGCTTGGTTTATGAAGTGAATGACAATAAGATTATCTTGCTGGTAATTGCTATTGGTAAA
CGTGGTAAACGGGTCGGAGATGCGGTTTATACCCTCGCCAATGAGAGGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9270.42 Da
• Isoelectric Point: 3.8209

>AT21001 WP_011146358.1 NC_005126:2489209-2489460 [Photorhabdus laumondii subsp. laumondii TTO1]
MAYQILTNLAASITDLKRNPMGTYLQGEGEAVAILNRNEPAFYCVPPELFAYYQELAEDAALNKIADERLENAEFVSVNL
DDL

Nucleotide

• Length: 252 bp

>AT21001 NC_005126:2489209-2489460 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGGCATATCAAATCTTAACAAATTTAGCGGCAAGTATTACCGATTTGAAACGTAACCCAATGGGGACATATTTGCAGGG
GGAAGGTGAAGCGGTCGCAATCCTGAATCGGAATGAACCTGCATTTTATTGTGTGCCTCCTGAATTATTCGCCTACTATC
AGGAGCTAGCAGAGGATGCCGCACTAAACAAAATTGCAGATGAACGTTTAGAAAATGCTGAATTTGTTAGTGTGAACCTG
GATGATCTATAG

Structures

Toxin

• AlphaFold DB: A0A6L9JHY5

Antitoxin

• AlphaFold DB: A0A6L9JPX9