210003

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2301744..2302362 Replicon chromosome
Accession NZ_CP079770
Organism Escherichia coli strain HL15

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag KYX58_RS12990 Protein ID WP_001291435.1
Coordinates 2302144..2302362 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag KYX58_RS12985 Protein ID WP_000344800.1
Coordinates 2301744..2302118 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYX58_RS12975 (2296833) 2296833..2298026 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KYX58_RS12980 (2298049) 2298049..2301198 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
KYX58_RS12985 (2301744) 2301744..2302118 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
KYX58_RS12990 (2302144) 2302144..2302362 + 219 WP_001291435.1 HHA domain-containing protein Toxin
KYX58_RS12995 (2302534) 2302534..2303085 + 552 WP_000102564.1 maltose O-acetyltransferase -
KYX58_RS13000 (2303201) 2303201..2303671 + 471 WP_000136192.1 YlaC family protein -
KYX58_RS13005 (2303835) 2303835..2305385 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
KYX58_RS13010 (2305427) 2305427..2305780 - 354 WP_000878140.1 DUF1428 domain-containing protein -
KYX58_RS13020 (2306159) 2306159..2306470 + 312 WP_000409911.1 MGMT family protein -
KYX58_RS13025 (2306501) 2306501..2307073 - 573 WP_000779842.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T210003 WP_001291435.1 NZ_CP079770:2302144-2302362 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T210003 NZ_CP104362:c4078882-4078598 [Salmonella enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT210003 WP_000344800.1 NZ_CP079770:2301744-2302118 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT210003 NZ_CP104362:c4079114-4078872 [Salmonella enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References