Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 1090002..1090528 | Replicon | chromosome |
| Accession | NZ_CP079770 | ||
| Organism | Escherichia coli strain HL15 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | KYX58_RS07010 | Protein ID | WP_000323025.1 |
| Coordinates | 1090241..1090528 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | KYX58_RS07005 | Protein ID | WP_000534858.1 |
| Coordinates | 1090002..1090241 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KYX58_RS06955 (1085097) | 1085097..1085252 | - | 156 | WP_000379575.1 | DUF1391 family protein | - |
| KYX58_RS06960 (1085419) | 1085419..1085826 | - | 408 | WP_000448564.1 | DNA-binding transcriptional dual regulator DicA | - |
| KYX58_RS06965 (1085910) | 1085910..1086140 | + | 231 | WP_000920568.1 | dicB transcriptional regulator DicC | - |
| KYX58_RS06970 (1086124) | 1086124..1086315 | + | 192 | Protein_1087 | hypothetical protein | - |
| KYX58_RS06975 (1086292) | 1086292..1086414 | + | 123 | Protein_1088 | hypothetical protein | - |
| KYX58_RS06980 (1086414) | 1086414..1086763 | + | 350 | Protein_1089 | hypothetical protein | - |
| KYX58_RS06985 (1087408) | 1087408..1088430 | + | 1023 | Protein_1090 | ISNCY family transposase | - |
| KYX58_RS06990 (1088551) | 1088551..1088700 | + | 150 | WP_011443592.1 | protein YdfW | - |
| KYX58_RS06995 (1089137) | 1089137..1089469 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| KYX58_RS07000 (1089672) | 1089672..1089977 | - | 306 | WP_001326990.1 | protein YdfV | - |
| KYX58_RS07005 (1090002) | 1090002..1090241 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| KYX58_RS07010 (1090241) | 1090241..1090528 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| KYX58_RS07015 (1090600) | 1090600..1090755 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| KYX58_RS07020 (1090925) | 1090925..1091599 | + | 675 | Protein_1097 | DUF968 domain-containing protein | - |
| KYX58_RS07025 (1091613) | 1091613..1092365 | + | 753 | WP_001047135.1 | antitermination protein | - |
| KYX58_RS07030 (1092643) | 1092643..1092732 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| KYX58_RS07035 (1092787) | 1092787..1092999 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| KYX58_RS07040 (1093300) | 1093300..1093515 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| KYX58_RS07045 (1093879) | 1093879..1094049 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| KYX58_RS07050 (1094269) | 1094269..1094484 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| KYX58_RS07055 (1094489) | 1094489..1094800 | + | 312 | WP_000189916.1 | YdfR family protein | - |
| KYX58_RS07060 (1094797) | 1094797..1095330 | + | 534 | WP_001092971.1 | lysozyme | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1080824..1105369 | 24545 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T210000 WP_000323025.1 NZ_CP079770:1090241-1090528 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T210000 NZ_CP104362:3602454-3602711 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCAAAACCCACATGACCACCTATTACTCACAAATCCCCAGCCT
GCATCTTAAGGGCGACTGGCTGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAGCAGCTTTATCAGGCTAAACAGGTGGTTAAGGGAATT
AAGGACGTGCTGGTTTAG
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCAAAACCCACATGACCACCTATTACTCACAAATCCCCAGCCT
GCATCTTAAGGGCGACTGGCTGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAGCAGCTTTATCAGGCTAAACAGGTGGTTAAGGGAATT
AAGGACGTGCTGGTTTAG
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT210000 WP_000534858.1 NZ_CP079770:1090002-1090241 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT210000 NZ_CP104362:c3602629-3602297 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|