Detailed information of TA system TA209988

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4300332..4300986
• Replicon: chromosome
• Accession: NZ_CP079767
• Organism: Escherichia coli strain SF10

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: S1EEB2
• Locus tag: KX927_RS23425
• Protein ID: WP_000244777.1
• Coordinates: 4300579..4300986 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: KX927_RS23420
• Protein ID: WP_029392880.1
• Coordinates: 4300332..4300598 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KX927_RS23395 (4295501)	4295501..4296244	+	744	WP_000951964.1	SDR family oxidoreductase	-
KX927_RS23400 (4296301)	4296301..4297734	-	1434	WP_001336277.1	6-phospho-beta-glucosidase BglA	-
KX927_RS23405 (4297779)	4297779..4298090	+	312	WP_001182957.1	N(4)-acetylcytidine aminohydrolase	-
KX927_RS23410 (4298254)	4298254..4298913	+	660	WP_000250274.1	hemolysin III family protein	-
KX927_RS23415 (4299109)	4299109..4300089	-	981	WP_000886062.1	tRNA-modifying protein YgfZ	-
KX927_RS23420 (4300332)	4300332..4300598	+	267	WP_029392880.1	FAD assembly factor SdhE	Antitoxin
KX927_RS23425 (4300579)	4300579..4300986	+	408	WP_000244777.1	protein YgfX	Toxin
KX927_RS23430 (4301026)	4301026..4301547	-	522	WP_001055874.1	flavodoxin FldB	-
KX927_RS23435 (4301659)	4301659..4302555	+	897	WP_000806638.1	site-specific tyrosine recombinase XerD	-
KX927_RS23440 (4302580)	4302580..4303290	+	711	WP_000715214.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
KX927_RS23445 (4303296)	4303296..4305029	+	1734	WP_000813200.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 16031.96 Da
• Isoelectric Point: 11.5202

>T209988 WP_000244777.1 NZ_CP079767:4300579-4300986 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Nucleotide

• Length: 408 bp

>T209988 NZ_CP104358:c4495231-4494920 [Salmonella enterica]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10520.10 Da
• Isoelectric Point: 5.1599

>AT209988 WP_029392880.1 NZ_CP079767:4300332-4300598 [Escherichia coli]
MDINSKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT209988 NZ_CP104358:c4494919-4494629 [Salmonella enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Toxin

• AlphaFold DB: A0A7U9LFV7