Detailed information of TA system TA209987

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 4228392..4228990
• Replicon: chromosome
• Accession: NZ_CP079767
• Organism: Escherichia coli strain SF10

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: KX927_RS23050
• Protein ID: WP_053270478.1
• Coordinates: 4228613..4228990 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: L4J1C0
• Locus tag: KX927_RS23045
• Protein ID: WP_001603498.1
• Coordinates: 4228392..4228613 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KX927_RS23015 (4223438)	4223438..4224937	+	1500	WP_000933250.1	inorganic phosphate transporter PitB	-
KX927_RS23020 (4224986)	4224986..4225678	-	693	WP_259553631.1	dTMP kinase	-
KX927_RS23025 (4225852)	4225852..4226565	+	714	WP_096179607.1	dTMP kinase	-
KX927_RS23030 (4226597)	4226597..4227148	+	552	Protein_4092	hypothetical protein	-
KX927_RS23035 (4227204)	4227204..4227901	+	698	WP_223367350.1	IS1 family transposase	-
KX927_RS23040 (4227926)	4227926..4228207	+	282	WP_259553636.1	fimbrial protein	-
KX927_RS23045 (4228392)	4228392..4228613	+	222	WP_001603498.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KX927_RS23050 (4228613)	4228613..4228990	+	378	WP_053270478.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
KX927_RS23055 (4229100)	4229100..4229315	-	216	Protein_4097	transposase	-
KX927_RS23060 (4229501)	4229501..4230763	-	1263	WP_076486553.1	integrase arm-type DNA-binding domain-containing protein	-
KX927_RS23070 (4231142)	4231142..4231849	-	708	WP_000234514.1	DUF554 domain-containing protein	-
KX927_RS23075 (4232002)	4232002..4232085	+	84	WP_211180506.1	protein YqgH	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4221287..4236969	15682
	-	inside	IScluster/Tn	-	-	4227608..4229315	1707

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (4-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-51)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13419.20 Da
• Isoelectric Point: 6.7260

>T209987 WP_053270478.1 NZ_CP079767:4228613-4228990 [Escherichia coli]
MRHISPEELIAIHDANISRYGGLPGMSDSGRAEAIIGRVQARVAYEEITGLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVYDSPELAELTVGAATGEVSVSTVVATLRRLYGTA

Nucleotide

• Length: 378 bp

>T209987 NZ_CP104358:c4185985-4185494 [Salmonella enterica]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8190.24 Da
• Isoelectric Point: 6.3159

>AT209987 WP_001603498.1 NZ_CP079767:4228392-4228613 [Escherichia coli]
MQSINFRTARSNLTEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDTTNKKLVNR

Nucleotide

• Length: 222 bp

>AT209987 NZ_CP104358:c4186275-4185982 [Salmonella enterica]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Structures

Antitoxin

• AlphaFold DB: L4J1C0