Detailed information of TA system TA209985

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4141074..4141909
• Replicon: chromosome
• Accession: NZ_CP079767
• Organism: Escherichia coli strain SF10

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A763DSF8
• Locus tag: KX927_RS22590
• Protein ID: WP_047928871.1
• Coordinates: 4141532..4141909 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: KX927_RS22585
• Protein ID: WP_047928872.1
• Coordinates: 4141074..4141442 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KX927_RS22545 (4136116)	4136116..4137552	+	1437	Protein_3995	autotransporter domain-containing protein	-
KX927_RS22550 (4137623)	4137623..4137856	+	234	WP_047928875.1	DUF905 family protein	-
KX927_RS22555 (4137947)	4137947..4138765	+	819	WP_096935434.1	DUF932 domain-containing protein	-
KX927_RS22560 (4138765)	4138765..4139034	+	270	WP_259553614.1	hypothetical protein	-
KX927_RS22565 (4139103)	4139103..4139576	+	474	WP_001355870.1	antirestriction protein	-
KX927_RS22570 (4139592)	4139592..4140068	+	477	WP_001186770.1	RadC family protein	-
KX927_RS22575 (4140137)	4140137..4140358	+	222	WP_000692312.1	DUF987 domain-containing protein	-
KX927_RS22580 (4140377)	4140377..4141024	+	648	WP_114493062.1	antitoxin of toxin-antitoxin stability system	-
KX927_RS22585 (4141074)	4141074..4141442	+	369	WP_047928872.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
KX927_RS22590 (4141532)	4141532..4141909	+	378	WP_047928871.1	TA system toxin CbtA family protein	Toxin
KX927_RS22595 (4141906)	4141906..4142055	+	150	Protein_4005	DUF5983 family protein	-
KX927_RS22600 (4142131)	4142131..4142328	+	198	WP_096093965.1	DUF957 domain-containing protein	-
KX927_RS22605 (4142413)	4142413..4143258	+	846	WP_072650597.1	DUF4942 domain-containing protein	-
KX927_RS22615 (4143558)	4143558..4144064	+	507	WP_000228937.1	G/U mismatch-specific DNA glycosylase	-
KX927_RS22620 (4144143)	4144143..4145984	-	1842	WP_000437375.1	RNA polymerase sigma factor RpoD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	rfaE	4131712..4196094	64382

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13941.88 Da
• Isoelectric Point: 7.3222

>T209985 WP_047928871.1 NZ_CP079767:4141532-4141909 [Escherichia coli]
MKTLPVLPGQAAGSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTHSQLINSIDILRARRATGLMTRDNYRTVNGITQGKHPEAKQ

Nucleotide

• Length: 378 bp

>T209985 NZ_CP104358:c4037781-4037473 [Salmonella enterica]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13757.47 Da
• Isoelectric Point: 5.0907

>AT209985 WP_047928872.1 NZ_CP079767:4141074-4141442 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEDNQLHYLADRAGIRGRFSDADAYHLDQALPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT209985 NZ_CP104358:c4038023-4037784 [Salmonella enterica]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Structures

Toxin

• AlphaFold DB: A0A763DSF8