Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 1543184..1543715 Replicon chromosome
Accession NC_005126
Organism Photorhabdus luminescens subsp. laumondii TTO1

Toxin (Protein)


Gene name relE Uniprot ID Q7N737
Locus tag PLU_RS06630 Protein ID WP_011145649.1
Coordinates 1543434..1543715 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q7N738
Locus tag PLU_RS06625 Protein ID WP_011145648.1
Coordinates 1543184..1543447 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PLU_RS06615 (plu1323) 1539045..1539494 + 450 WP_011145646.1 cupin domain-containing protein -
PLU_RS06620 (plu1324) 1540188..1542863 + 2676 WP_011145647.1 beta-N-acetylhexosaminidase -
PLU_RS06625 (plu1325) 1543184..1543447 + 264 WP_011145648.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PLU_RS06630 (plu1326) 1543434..1543715 + 282 WP_011145649.1 type II toxin-antitoxin system YafQ family toxin Toxin
PLU_RS06635 (plu1327) 1543814..1544260 - 447 WP_011145650.1 ferric iron uptake transcriptional regulator -
PLU_RS06640 (plu1328) 1544626..1545156 - 531 WP_011145651.1 flavodoxin FldA -
PLU_RS06645 (plu1329) 1545331..1545618 - 288 WP_011145652.1 LexA regulated protein -
PLU_RS06650 (plu1330) 1545757..1546725 - 969 WP_041379984.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-72)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10893.59 Da        Isoelectric Point: 6.4735

>T20998 WP_011145649.1 NC_005126:1543434-1543715 [Photorhabdus laumondii subsp. laumondii TTO1]
MRTIDYASQFKRDYKREKKGRHREVLDDVLMLMIELLASDSLLEPKYCDHALSGDWKDFRDCHIKPDLILIYQKPDADTL
CLVRLGSHSELGL

Download         Length: 282 bp

>T20998 NC_005126:1543434-1543715 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGCGGACGATTGACTACGCAAGCCAATTCAAGCGAGATTACAAGAGAGAAAAGAAAGGTCGGCATCGTGAAGTTCTTGA
TGACGTACTGATGCTGATGATTGAATTATTAGCTTCTGATAGTTTGCTAGAGCCGAAATATTGCGATCATGCTCTTTCTG
GTGATTGGAAGGATTTTCGAGATTGTCATATCAAGCCTGACTTGATACTGATTTATCAGAAACCCGATGCGGACACATTG
TGCCTTGTCCGTCTTGGCTCTCACTCAGAGCTTGGCTTATAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9367.91 Da        Isoelectric Point: 5.0649

>AT20998 WP_011145648.1 NC_005126:1543184-1543447 [Photorhabdus laumondii subsp. laumondii TTO1]
MATNQLVQTRIDGEIKTEAAAVLAAMGLTVSDAVRMMLTRVAREKVLPFEPLVPNETTIAAMKEARKGCGKSFSTVKDLM
ADLNADD

Download         Length: 264 bp

>AT20998 NC_005126:1543184-1543447 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGGCTACAAACCAATTAGTACAAACCCGTATTGATGGAGAGATTAAGACAGAGGCAGCTGCTGTTCTGGCTGCTATGGG
TTTGACTGTATCAGATGCTGTTCGCATGATGTTAACGCGGGTAGCAAGAGAAAAAGTGTTACCTTTTGAACCGTTAGTAC
CAAATGAGACAACAATAGCTGCAATGAAAGAAGCTCGCAAAGGTTGCGGTAAATCATTCTCCACTGTAAAAGATTTAATG
GCTGATCTTAATGCGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JJR2

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JP47

References