Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1229753..1230391 Replicon chromosome
Accession NZ_CP079767
Organism Escherichia coli strain SF10

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag KX927_RS08400 Protein ID WP_000813794.1
Coordinates 1230215..1230391 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KX927_RS08395 Protein ID WP_001270286.1
Coordinates 1229753..1230169 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KX927_RS08375 (1224905) 1224905..1225846 - 942 WP_001251304.1 ABC transporter permease -
KX927_RS08380 (1225847) 1225847..1226860 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
KX927_RS08385 (1226878) 1226878..1228023 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
KX927_RS08390 (1228268) 1228268..1229674 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
KX927_RS08395 (1229753) 1229753..1230169 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
KX927_RS08400 (1230215) 1230215..1230391 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
KX927_RS08405 (1230613) 1230613..1230843 + 231 WP_000494244.1 YncJ family protein -
KX927_RS08410 (1230935) 1230935..1232896 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
KX927_RS08415 (1232969) 1232969..1233505 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
KX927_RS08420 (1233597) 1233597..1234772 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T209976 WP_000813794.1 NZ_CP079767:c1230391-1230215 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T209976 NZ_CP104358:358943-359218 [Salmonella enterica]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT209976 WP_001270286.1 NZ_CP079767:c1230169-1229753 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT209976 NZ_CP104358:358680-358940 [Salmonella enterica]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References