209965

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 92632..93158 Replicon plasmid pSF10EC-2
Accession NZ_CP079766
Organism Escherichia coli strain SF10

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag KX927_RS01945 Protein ID WP_000323025.1
Coordinates 92632..92919 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag KX927_RS01950 Protein ID WP_000534858.1
Coordinates 92919..93158 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KX927_RS01910 88229..88309 - 81 Protein_96 hypothetical protein -
KX927_RS01915 (KX927_01890) 88297..88722 + 426 Protein_97 IS3 family transposase -
KX927_RS01920 89234..89356 + 123 WP_001406634.1 hypothetical protein -
KX927_RS01925 (KX927_01895) 89395..90903 + 1509 WP_141223309.1 group II intron reverse transcriptase/maturase -
KX927_RS01930 (KX927_01900) 90984..91473 + 490 Protein_100 IS3 family transposase -
KX927_RS01935 (KX927_01905) 91479..91688 - 210 WP_072662162.1 hypothetical protein -
KX927_RS01940 (KX927_01910) 92125..92349 - 225 Protein_102 hypothetical protein -
KX927_RS01945 (KX927_01915) 92632..92919 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
KX927_RS01950 (KX927_01920) 92919..93158 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
KX927_RS01955 93183..93293 + 111 Protein_105 protein YdfV -
KX927_RS01960 (KX927_01925) 93500..93649 + 150 WP_000550473.1 hypothetical protein -
KX927_RS01965 (KX927_01930) 93693..94766 + 1074 WP_000557466.1 hypothetical protein -
KX927_RS01970 (KX927_01935) 94843..95547 + 705 WP_001067852.1 IS6-like element IS26 family transposase -
KX927_RS01975 (KX927_01940) 95553..96077 + 525 WP_232379235.1 Ig-like domain-containing protein -
KX927_RS01980 (KX927_01945) 96420..97124 - 705 WP_001067858.1 IS6-like element IS26 family transposase -
KX927_RS01985 (KX927_01950) 97188..97310 + 123 Protein_111 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid floR / qnrS1 / tet(A) - 1..127890 127890
- inside IScluster/Tn - - 83139..98839 15700


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T209965 WP_000323025.1 NZ_CP079766:c92919-92632 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T209965 NZ_CP104356:1145375-1146313 [Vibrio cholerae]
ATGGATAAAGATAGCCCATACTACAAACAGGTTTCCTTGCTCATAAGAATGCTTCCTGTGGTAGCCACAGAGACAGTTTT
TGCACTTAAAGGTGGCACCGCCATTAATTTATTTGTGAGAGATTTTCCTCGGTTATCTGTAGATATTGATCTTGCTTATC
TTCCACTTGAACCAAGAGATGAGGCTTTGATTAATGTCAGGGCTGCATTGCAGCGCATTACAGACAGAATCAATACTCAA
CCAGATATCAGAGCGGCATTTCAGGATAATAAAGCTGATGAACTGAGAATAGTTGTATCAAGTCCGGTTGCGACGATCAA
AATTGAAGTGTCACCCGTCGCCAGAGGTACATTGCATAGTGCAGAAATAATGCCAGTTCAAGAGTCTGTTGAAGACGAGT
TTGGTTATGCTGAGATTCAGGTAGTCAGTCTTCCCGATCTGTATGGTGGGAAATTGTGTGCTGCAATGGATCGCCAACAT
CCTCGCGACTTATTTGATGTGCGAATGTTACTTGGTAGTGAAGGGATTTCGAGAGAGATTTTGGTGGGTTTTTTAACCTA
TACATTAAGTCACCCTCGGCCTATTAATGAAGTCATGTCGCCAAACTGGCAGCCTCTAAATGAGAAATTTCAGGCAGAAT
TTGACGGAATGACTTTTGAAAAAGTTGAATGCGAAGACTTAGCCTCTGTTAGGCCCATGATGTTAATTGAACTGCAAAAA
CATTTCACAGAAAGGGATCATGCTTTCCTTATGTCATTCAAAAGAGGACAACCTGACTGGGCATTGTTTGACTATCCTAA
AGCAGCAGACTTGCCAGCGATTCGTTGGAAGTTGCAGAACATTAACAAATTGGCAAAGAATCAAGCAAAACATCAAGAGC
AATTAGATAAATTGAAGCAAGTGCTTGATGATTGGCTTGTTAACGCAAACGCCGAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT209965 WP_000534858.1 NZ_CP079766:c93158-92919 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT209965 NZ_CP104356:1144591-1145382 [Vibrio cholerae]
ATGTCATCTAAGATAAACTGGCTTGTTGCTCATACTTCTCCTGGTGCGCTAGTACTTCAGCAATGGCTGACTGAAAACGG
CGTAAGCTACTCGTTGGCTCAGAAGTACGCGCAGAACGGTTGGCTGAAGAAGCTTAGTTCTGGTGTGTACTATCGTCCAA
ATGCGCAAGGCGATATAAAGCCAACTTGGGTTGATGCCATTCAAGCATTAGATGTGCAATTGGGCGTTTCAGTTCATTTG
GCTGGATTGAGCAGCTTAACTCACCAAGGACTGAGTCACTATCTACAGCTGAACAAAGAGCAAGTTTGGATTTGCGTTAA
AAACAAGTCGTCCTTACCAAAATGGTTTCGTGAATTCCCTTATCAGAATTGGTTTTACTGTGGAAACCATAAGCTTGAAG
TGAATCCCGAGAAAGATTTGAAAAGGATCACGGTTAAAGAGAAAGAGCTCACTGTCAGCTGTGCAGAACTTGCTGCCTAT
GAAGTGGTAGACGCGATTGGGAAGCTGATTTCATTTGAGCATGTCGCAGAATTATTTCAGGGTCTAGTCAATCTTAGCCC
TAGAAAAGTACAAGATATTCTTGAGCGAAGCAGCTCTGTTCAGGCAAACCGAATATTTCTATTTCTGGGTCGATACTACG
ATCACCAGTGGGTCAATCGCATAGATGAAACAAGAATTAAATTGGGTGCAGGAAAGCGGCAGGTTGTCGAAAAAGGACGT
TTTGATGAGCGATATCAAATCACAGTGCCAGAGATATTAAGCGTCAAAAAAGGTGAACAACATAATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References