Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4106591..4107107 Replicon chromosome
Accession NZ_CP079762
Organism Klebsiella pneumoniae strain JP20

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag KYE76_RS20025 Protein ID WP_004178374.1
Coordinates 4106823..4107107 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KYE76_RS20020 Protein ID WP_002886901.1
Coordinates 4106591..4106833 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYE76_RS20005 (4102619) 4102619..4103359 + 741 WP_002886899.1 KDGP aldolase family protein -
KYE76_RS20010 (4103426) 4103426..4104580 + 1155 WP_004178372.1 lactonase family protein -
KYE76_RS20015 (4104603) 4104603..4106513 + 1911 WP_004178373.1 PRD domain-containing protein -
KYE76_RS20020 (4106591) 4106591..4106833 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KYE76_RS20025 (4106823) 4106823..4107107 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KYE76_RS20030 (4107111) 4107111..4107575 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KYE76_RS20035 (4107816) 4107816..4109954 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KYE76_RS20040 (4110311) 4110311..4111054 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KYE76_RS20045 (4111057) 4111057..4111230 - 174 WP_032408826.1 hypothetical protein -
KYE76_RS20050 (4111360) 4111360..4111623 + 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T209959 WP_004178374.1 NZ_CP079762:4106823-4107107 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T209959 NZ_CP104355:650006-650272 [Vibrio cholerae]
ATGATTAAGTTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
GTTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCGGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT209959 WP_002886901.1 NZ_CP079762:4106591-4106833 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT209959 NZ_CP104355:649887-649985 [Vibrio cholerae]
GTGGTTGCAGTTGTTGTGTTTGAGTTTGGTGTTATGCGTTGTCAGCCCCTTAGGCGGGCGTTAGCCGTCATCAATAAACA
AAGTTTGCCTAATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References