Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2720129..2720786 Replicon chromosome
Accession NZ_CP079762
Organism Klebsiella pneumoniae strain JP20

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KYE76_RS13285 Protein ID WP_002916310.1
Coordinates 2720129..2720539 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KYE76_RS13290 Protein ID WP_002916312.1
Coordinates 2720520..2720786 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYE76_RS13265 (2716129) 2716129..2717862 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
KYE76_RS13270 (2717868) 2717868..2718581 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KYE76_RS13275 (2718604) 2718604..2719500 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KYE76_RS13280 (2719601) 2719601..2720122 + 522 WP_004144730.1 flavodoxin FldB -
KYE76_RS13285 (2720129) 2720129..2720539 - 411 WP_002916310.1 protein YgfX Toxin
KYE76_RS13290 (2720520) 2720520..2720786 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KYE76_RS13295 (2721032) 2721032..2722015 + 984 WP_020324927.1 tRNA-modifying protein YgfZ -
KYE76_RS13300 (2722166) 2722166..2722825 - 660 WP_002916317.1 hemolysin III family protein -
KYE76_RS13305 (2722989) 2722989..2723300 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KYE76_RS13310 (2723350) 2723350..2724078 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KYE76_RS13315 (2724197) 2724197..2725630 + 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T209954 WP_002916310.1 NZ_CP079762:c2720539-2720129 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T209954 NZ_CP104354:c1140084-1139761 [Vibrio cholerae]
ATGAGCTGGAAGATCGACTTTTACGATGGCGTTGAGGATCAGATCCTCGATATGCCACCCAAAATACAAGCTCGCATGAT
TAAGCTTTTAGAGCTGATGGAAAAGCATGGTGCAAACTTGGGGCCTCCTCATACTGAGTCTATGGGCGATGGGTTATTTG
AAATCCGCGCCAAAGCTCAAGAAGGTATTGGTAGAGGCTTATTTTGCTACTTAAAAGGGAAGCACATTTATGTGTTACAC
GCTTTTGTAAAAAAATCTCAAAAGACGCCCAAAAATGAGCTCAATCTTGCCAGAGATAGACAAAAAGAGGTTCAAAAATC
ATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT209954 WP_002916312.1 NZ_CP079762:c2720786-2720520 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT209954 NZ_CP104354:c1139764-1139486 [Vibrio cholerae]
ATGAGTCTGCAAAAACTGAAACAACGTGCTTTAGCCAATGCTGAAGTTAAGAATGAGTACGATAAGCTTGAGAGTGAGTT
CAGCTTTATTGATCAATTGCTTACCATGAGAACAAAGGCAGGACTTACTCAAGAGCAGGTTGCTGAAAGAATGCATACCC
AAAAAAGTAATGTCAGTCGTTTAGAAAAAGGCAATGCCAATCCAAGTTGGTCAACTCTTCTAAAATATGCTCACGCATGT
GGCTTTGAACTAACACTCAAGCCACAAAAAATGAGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References