Detailed information of TA system TA209945

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 897159..898747
• Replicon: chromosome
• Accession: NZ_CP079762
• Organism: Klebsiella pneumoniae strain JP20

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: KYE76_RS04330
• Protein ID: WP_004179815.1
• Coordinates: 897425..898747 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KYE76_RS04325
• Protein ID: WP_004176198.1
• Coordinates: 897159..897425 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KYE76_RS04300 (892309)	892309..893232	+	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-
KYE76_RS04305 (893213)	893213..894367	-	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
KYE76_RS04310 (894713)	894713..896092	+	1380	WP_004179808.1	nucleobase:cation symporter-2 family protein	-
KYE76_RS04315 (896070)	896070..896570	+	501	WP_004179811.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
KYE76_RS04320 (896567)	896567..896893	+	327	WP_002904788.1	hydroxyisourate hydrolase	-
KYE76_RS04325 (897159)	897159..897425	+	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
KYE76_RS04330 (897425)	897425..898747	+	1323	WP_004179815.1	type II toxin-antitoxin system HipA family toxin	Toxin
KYE76_RS04335 (898764)	898764..900056	-	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
KYE76_RS04340 (900198)	900198..901202	-	1005	WP_004179822.1	fimbrial protein	-
KYE76_RS04345 (901190)	901190..903691	-	2502	WP_020323802.1	fimbria/pilus outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49152.42 Da
• Isoelectric Point: 7.2850

>T209945 WP_004179815.1 NZ_CP079762:897425-898747 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T209945 NZ_CP104350:2516495-2516677 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAAGGGTTAGTTACAATCTCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT209945 WP_004176198.1 NZ_CP079762:897159-897425 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT209945 NZ_CP104350:2516770-2517174 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG