20994

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 816018..816646 Replicon chromosome
Accession NC_005126
Organism Photorhabdus luminescens subsp. laumondii TTO1

Toxin (Protein)


Gene name hicA Uniprot ID Q7N8L3
Locus tag PLU_RS03530 Protein ID WP_011145083.1
Coordinates 816371..816646 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q7N8L4
Locus tag PLU_RS03525 Protein ID WP_011145082.1
Coordinates 816018..816374 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PLU_RS03505 (plu0702) 811020..811382 - 363 WP_011145078.1 6-carboxytetrahydropterin synthase QueD -
PLU_RS03510 (plu0703) 811649..813451 + 1803 WP_011145079.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -
PLU_RS03515 (plu0704) 813451..815181 + 1731 WP_011145080.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
PLU_RS03520 (plu0705) 815178..815912 + 735 WP_011145081.1 phosphoadenylyl-sulfate reductase -
PLU_RS03525 (plu0706) 816018..816374 - 357 WP_011145082.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PLU_RS03530 (plu0707) 816371..816646 - 276 WP_011145083.1 type II toxin-antitoxin system HicA family toxin Toxin
PLU_RS03535 (plu0708) 816914..818326 + 1413 WP_011145084.1 siroheme synthase CysG -
PLU_RS03540 (plu0709) 818336..819244 + 909 WP_011145085.1 sulfate adenylyltransferase subunit CysD -
PLU_RS03545 (plu0710) 819256..820698 + 1443 WP_041379914.1 sulfate adenylyltransferase subunit CysN -
PLU_RS03550 (plu0711) 820700..821332 + 633 WP_011145087.1 adenylyl-sulfate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-85)

Antitoxin

Uncharacterised protein family HicB

(59-111)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10236.91 Da        Isoelectric Point: 9.9633

>T20994 WP_011145083.1 NC_005126:c816646-816371 [Photorhabdus laumondii subsp. laumondii TTO1]
MKEQVSMLRKRQKNTLEQIFKMPVPAGIKWSDVESLIIALGGEVKEGKGSRCRLLLNDSIARFHRPHPSPDTDKGAVVSL
REWLESIGVEP

Download         Length: 276 bp

>T20994 NC_005126:c816646-816371 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGAAAGAACAGGTTTCAATGCTCAGGAAGAGGCAAAAAAATACGTTGGAGCAGATATTTAAAATGCCTGTTCCTGCGGG
AATTAAGTGGTCTGACGTGGAATCACTCATAATCGCTCTGGGAGGTGAGGTTAAAGAGGGGAAAGGTTCACGTTGCAGGC
TGTTGCTAAACGATAGTATTGCCAGATTTCACCGTCCACATCCCTCACCAGATACTGACAAAGGGGCCGTCGTCAGCCTA
CGAGAATGGTTAGAAAGCATAGGAGTTGAGCCATGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13321.23 Da        Isoelectric Point: 5.5798

>AT20994 WP_011145082.1 NC_005126:c816374-816018 [Photorhabdus laumondii subsp. laumondii TTO1]
MKMTVQNTMVIAGQQAIISYVPEIGMFRGKFLGLSGYCDFISDSIQGLQDEGKISLHEYLEDCNASGIEPYARQEKIKTF
TLRYPESFGERLHCAAAEHQISVNAFIIETLNERMKHA

Download         Length: 357 bp

>AT20994 NC_005126:c816374-816018 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGAAGATGACAGTACAAAATACAATGGTAATAGCCGGACAGCAGGCTATTATTAGCTACGTGCCAGAAATTGGCATGTT
CAGGGGTAAATTTTTAGGGCTGTCTGGTTATTGTGATTTTATCTCTGATAGTATTCAGGGGTTGCAAGATGAGGGTAAAA
TATCTCTACATGAATATCTTGAAGATTGTAACGCATCAGGTATTGAACCTTATGCAAGGCAAGAAAAAATCAAAACATTT
ACTCTGCGCTACCCCGAATCATTTGGAGAGCGATTGCATTGCGCAGCAGCCGAGCATCAGATTTCGGTGAATGCGTTCAT
CATTGAAACTTTAAATGAACGAATGAAACACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JQS1

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JRP4

References