Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 507128..507764 Replicon chromosome
Accession NZ_CP079759
Organism Bacillus sp. LJBS17

Toxin (Protein)


Gene name mazF Uniprot ID G4NU33
Locus tag KXZ66_RS02570 Protein ID WP_003156187.1
Coordinates 507414..507764 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G4NU32
Locus tag KXZ66_RS02565 Protein ID WP_003225183.1
Coordinates 507128..507409 (+) Length 94 a.a.

Genomic Context

KXZ66_RS02550KXZ66_RS02555KXZ66_RS02560KXZ66_RS02565KXZ66_RS02570KXZ66_RS02575KXZ66_RS02580KXZ66_RS02585KXZ66_RS02590KXZ66_RS02595KXZ66_RS02600KXZ66_RS02605KXZ66_RS02610KXZ66_RS02545
Location: 504181..504546 (366 bp)
Type: Others
Protein ID: WP_015252768.1
Location: 504712..505728 (1017 bp)
Type: Others
Protein ID: WP_003234282.1
Location: 505843..507012 (1170 bp)
Type: Others
Protein ID: WP_219144776.1
Location: 507128..507409 (282 bp)
Type: Antitoxin
Protein ID: WP_003225183.1
Location: 507414..507764 (351 bp)
Type: Toxin
Protein ID: WP_003156187.1
Location: 507879..508703 (825 bp)
Type: Others
Protein ID: WP_009966610.1
Location: 508708..509073 (366 bp)
Type: Others
Protein ID: WP_003225190.1
Location: 509077..509478 (402 bp)
Type: Others
Protein ID: WP_003225192.1
Location: 509490..510497 (1008 bp)
Type: Others
Protein ID: WP_014478900.1
Location: 510566..510895 (330 bp)
Type: Others
Protein ID: WP_014475877.1
Location: 510892..511374 (483 bp)
Type: Others
Protein ID: WP_021481702.1
Location: 511340..512128 (789 bp)
Type: Others
Protein ID: WP_003246715.1
Location: 512128..512727 (600 bp)
Type: Others
Protein ID: WP_021481701.1
Location: 503487..504086 (600 bp)
Type: Others
Protein ID: WP_219144775.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KXZ66_RS02545 (503487)503487..504086-600WP_219144775.1rhomboid family intramembrane serine protease-
KXZ66_RS02550 (504181)504181..504546+366WP_015252768.1holo-ACP synthase-
KXZ66_RS02555 (504712)504712..505728+1017WP_003234282.1outer membrane lipoprotein carrier protein LolA-
KXZ66_RS02560 (505843)505843..507012+1170WP_219144776.1alanine racemase-
KXZ66_RS02565 (507128)507128..507409+282WP_003225183.1type II toxin-antitoxin system antitoxin EndoAIAntitoxin
KXZ66_RS02570 (507414)507414..507764+351WP_003156187.1type II toxin-antitoxin system endoribonuclease NdoAToxin
KXZ66_RS02575 (507879)507879..508703+825WP_009966610.1RsbT co-antagonist protein RsbRA-
KXZ66_RS02580 (508708)508708..509073+366WP_003225190.1RsbT antagonist protein RsbS-
KXZ66_RS02585 (509077)509077..509478+402WP_003225192.1serine/threonine-protein kinase RsbT-
KXZ66_RS02590 (509490)509490..510497+1008WP_014478900.1phosphoserine phosphatase RsbU-
KXZ66_RS02595 (510566)510566..510895+330WP_014475877.1anti-sigma factor antagonist RsbV-
KXZ66_RS02600 (510892)510892..511374+483WP_021481702.1anti-sigma B factor RsbW-
KXZ66_RS02605 (511340)511340..512128+789WP_003246715.1RNA polymerase sigma factor SigB-
KXZ66_RS02610 (512128)512128..512727+600WP_021481701.1phosphoserine phosphatase RsbX-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8781

>T209933 WP_003156187.1 NZ_CP079759:507414-507764 [Bacillus sp. LJBS17]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF

Download         Length: 351 bp

>T209933 NZ_CP104345:145981-146268 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCGATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATACGAATCATTAGT
GCAAGGCAAGTGACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10546.92 Da        Isoelectric Point: 6.4708

>AT209933 WP_003225183.1 NZ_CP079759:507128-507409 [Bacillus sp. LJBS17]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG

Download         Length: 282 bp

>AT209933 NZ_CP104345:146255-146569 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACGCAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACCGATTGGAGCAGTGCTGTACGCC
AAAATCAATTTTACCGCCCAGTGAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGAATGAATGAAATTTTACGGGATGCTATGCTGAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB4MDX
PDB4ME7
PDB1NE8

Antitoxin

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Source
ID
Structure
PDB4ME7
AlphaFold DBG4NU32

References