Detailed information of TA system TA209931

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 4565748..4567443
• Replicon: chromosome
• Accession: NZ_CP079758
• Organism: Pseudomonas aeruginosa strain PA0386

Toxin (Protein)

• Gene name: doc
• Uniprot ID: Q9HYA0
• Locus tag: KYE95_RS21260
• Protein ID: WP_003112901.1
• Coordinates: 4566574..4567443 (-)
• Length: 290 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: Q9HYA1
• Locus tag: KYE95_RS21255
• Protein ID: WP_003112902.1
• Coordinates: 4565748..4566581 (-)
• Length: 278 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KYE95_RS21235 (KYE95_21165)	4560979..4562463	-	1485	WP_003112906.1	aldehyde dehydrogenase	-
KYE95_RS21240 (KYE95_21170)	4562475..4563278	-	804	WP_003112905.1	aspartate dehydrogenase	-
KYE95_RS21245 (KYE95_21175)	4563289..4564971	-	1683	WP_003112904.1	thiamine pyrophosphate-binding protein	-
KYE95_RS21250 (KYE95_21180)	4564964..4565761	-	798	WP_003112903.1	SDR family oxidoreductase	-
KYE95_RS21255 (KYE95_21185)	4565748..4566581	-	834	WP_003112902.1	IclR family transcriptional regulator	Antitoxin
KYE95_RS21260 (KYE95_21190)	4566574..4567443	-	870	WP_003112901.1	alpha/beta hydrolase	Toxin
KYE95_RS21265 (KYE95_21195)	4567452..4567982	-	531	WP_003112900.1	cupin domain-containing protein	-
KYE95_RS21270 (KYE95_21200)	4567996..4568757	-	762	WP_003112899.1	SDR family oxidoreductase	-
KYE95_RS21275 (KYE95_21205)	4568763..4569539	-	777	WP_003112898.1	ABC transporter permease	-
KYE95_RS21280 (KYE95_21210)	4569536..4570543	-	1008	WP_003112897.1	ABC transporter substrate-binding protein	-
KYE95_RS21285 (KYE95_21215)	4570584..4571435	-	852	WP_003130104.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (41-272)

Antitoxin

• Transcription regulator IclR, N-terminal (16-66)

Sequences

Toxin

Protein

• Length: 290 a.a.
• Molecular weight: 30403.60 Da
• Isoelectric Point: 6.5894

>T209931 WP_003112901.1 NZ_CP079758:c4567443-4566574 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Nucleotide

• Length: 870 bp

>T209931 NZ_CP104343:c201746-201444 [Acinetobacter baumannii]
ATGTACTCAATATATACCACTGAAGTCTTTGATGACTGGTTCACCAAGTTAAAAGACCAGCAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAGCCGGTCGGTGAAGGTGTTTCTGAATTACGTTTCT
TCTTTGGGCCAGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTTGTTATTCTTTTAGCAGGCGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTGCAATTGGCACAAGATTTAGAGGAGGAGCTATAA

Antitoxin

Protein

• Length: 278 a.a.
• Molecular weight: 30877.26 Da
• Isoelectric Point: 5.7725

>AT209931 WP_003112902.1 NZ_CP079758:c4566581-4565748 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Nucleotide

• Length: 834 bp

>AT209931 NZ_CP104343:c201443-201162 [Acinetobacter baumannii]
ATGGCTATTAAACTTCGCAAATGGGACAGTGCTGAGCATCTTAAAACAGAGGATGATATGCAGGCTTACTTACAAGCATG
TATTGAAGAATCTAATGGCGATGCCGCATTCATTGCAAAGGCTTTAGGTAACATTGCAAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGCTTAGGCCGAGAAAGTCTTTATAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCAATTTAA

Structures

Toxin

• AlphaFold DB: Q9HYA0

Antitoxin

• AlphaFold DB: Q9HYA1